Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>GlyH-101

GlyH-101

GlyH-101 Structure
GlyH-101 structure
CAS No.
328541-79-3
Chemical Name:
GlyH-101
Synonyms
CS-1049;GLYH-101;CFTR Inhibitor II;CFTR Inhibitor II, GlyH-101;CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem;Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II;GLYH-101;CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBITOR II;N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;N-2-NAPHTHALENYL-2-[(3,5-DIBROMO-2,4-DIHYDROXYPHENYL)METHYLENE]GLYCINE HYDRAZIDE;N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
CBNumber:
CB62446668
Molecular Formula:
C19H15Br2N3O3
Molecular Weight:
493.15
MDL Number:
MFCD01532954
MOL File:
328541-79-3.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
Request For Quotation

GlyH-101 Properties

Melting point >300℃ (ethanol )
Density 1.73±0.1 g/cm3(Predicted)
storage temp. = -70C
solubility DMF:30.0(Max Conc. mg/mL);60.83(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.01(Max Conc. mM)
DMSO:57.58(Max Conc. mg/mL);116.75(Max Conc. mM)
form Yellow solid
pka 5.44±0.45(Predicted)

GlyH-101 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 219675 InSolutionCFTRInhibitorII,GlyH-101-CAS328541-79-3-Calbiochem 328541-79-3 5mg $230 2024-03-01 Buy
Sigma-Aldrich 219671 CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem
CFTR Inhibitor II, GlyH-101, CAS 328541-79-3, is a cell-permeable potent, selective and reversible open-channel blocker of CFTR (Ki = 4.3 μM in CFTR-expressing FRT cells). 		328541-79-3 5mg $216 2024-03-01 Buy
Cayman Chemical 15772 CFTR Inhibitor II ≥95% 328541-79-3 5mg $41 2024-03-01 Buy
Cayman Chemical 15772 CFTR Inhibitor II ≥95% 328541-79-3 25mg $142 2024-03-01 Buy
Cayman Chemical 15772 CFTR Inhibitor II ≥95% 328541-79-3 50mg $263 2024-03-01 Buy
Product number Packaging Price Buy
219675 5mg $230 Buy
219671 5mg $216 Buy
15772 5mg $41 Buy
15772 25mg $142 Buy
15772 50mg $263 Buy

GlyH-101 Chemical Properties,Uses,Production

Description

The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 μM). This compound binds to a site at the external pore of CFTR, occluding the pore and rapidly preventing chloride transport. Intraluminal CFTR inhibitor II greatly reduces intestinal fluid secretion induced by cholera toxin. It is effective in cells in culture and also in nasal and intestinal epithelia in vivo.

Uses

N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a glycine hydrazide that has recently been shown to block CFTR channels. However, its effects on cardiomyocytes are unknown. Studies have demonstrated that GlyH-101 blocks cardiac I Cl.PKA channels in a similar fashion to that reported for recombinant CFTR.

Definition

ChEBI: Glycine, n-2-naphthalenyl-, 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a member of naphthalenes.

General Description

A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 μM; Ki = 4.3 μM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

GlyH-101 Preparation Products And Raw materials

Raw materials

Preparation Products

GlyH-101 Suppliers

Global( 81)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Boyle Chemical Co., Ltd. 55

View Lastest Price from GlyH-101 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE pictures 2019-12-24 (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE
328541-79-3
 US $1.00 / g 1g 99% 20kg Career Henan Chemical Co

GlyH-101 Spectrum

(NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE(328541-79-3)MS

328541-79-3(GlyH-101)Related Search:

GlyH-101
(NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE GLYH-101 Glycine, N-2-naphthalenyl-, [(3,5-dibroMo-2,4-dihydroxyphenyl)Methylene]hydrazide N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide GlyH 101 N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide CFTR Inhibitor II CFTR Inhibitor II, GlyH-101 N'-[(3,5-DIBROMO-4-HYDROXY-6-OXOCYCLOHEXA-2,4-DIEN-1-YLIDENE)METHYL]-2-(NAPHTHALEN-2-YLAMINO)ACETOHYDRAZIDE CFTR Inhibitor II N-2-NAPHTHALENYL-2-[(3,5-DIBROMO-2,4-DIHYDROXYPHENYL)METHYLENE]GLYCINE HYDRAZIDE CS-1049 Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II GLYH-101;CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBITOR II CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem GLYH-101;CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBITOR II;GLYH 101;GLYH101 Glycine, N-2-naphthalenyl-, 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide Inhibitor,antiproliferative,PCT,inhibit,PS120 cells,GlyH101,intestinal fluid,GlyH-101,VSORC,CFTR-like current,Cystic fibrosis transmembrane conductance regulator,CFTR N'-(3,5-Dibromo-2,4-dihydroxybenzylidene)-2-(naphthalen-2-ylamino)acetohydrazide N'-(3,5-Dibromo-2,4-dihydroxybenzylidene)-2-(naphthalen-2-ylamino)acetohydrazide 328541-79-3 C19H15Br2N3O3 Inhibitors CFTR Inhibitor II, GlyH-101 is a cell-permeable glycinyl hydrazone compound.