ChemicalBook >> CAS DataBase List >>2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine structure

CAS No.: 3605-01-4

Chemical Name:: 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

Synonyms: PIRIBEDIL;ET-495;EU-4200;Piribedi;Pirbedil;Trivastan;Trivastal;Piribendyl;PIRIBEDIOL;Piribedil>

CBNumber:: CB6261328

Molecular Formula:: C16H18N4O2

Molecular Weight:: 298.34

MDL Number:: MFCD00868264

MOL File:: 3605-01-4.mol

MSDS File:: SDS

Last updated:2023-12-22 17:53:22

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2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Properties

Melting point	98°
Boiling point	439.76°C (rough estimate)
Density	1.1183 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	7.17±0.10(Predicted)
form	Solid
color	White
Merck	14,7493
CAS DataBase Reference	3605-01-4(CAS DataBase Reference)
FDA UNII	DO22K1PRDJ
ATC code	N04BC08

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

RTECS

UV9704000

HS Code

2933.59.8000

Toxicity

LD50 in mice (mg/kg): 88 i.v., 690 i.p., 1460 orally (Laubie)

NFPA 704

	0
1		0

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	P2054	Piribedil >98.0%(GC)(T)	3605-01-4	200mg	$26	2024-03-01	Buy
TCI Chemical	P2054	Piribedil >98.0%(GC)(T)	3605-01-4	1g	$69	2021-12-16	Buy
Usbiological	019806	Piribedil	3605-01-4	100mg	$460	2021-12-16	Buy
TRC	P508750	Piribedil	3605-01-4	100mg	$150	2021-12-16	Buy
TRC	P508750	Piribedil	3605-01-4	1g	$1190	2021-12-16	Buy

Product number	Packaging	Price	Buy
P2054	200mg	$26	Buy
P2054	1g	$69	Buy
019806	100mg	$460	Buy
P508750	100mg	$150	Buy
P508750	1g	$1190	Buy

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Trivastal, Eutherapie ,France,1969

Uses

Piribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impairment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.

Definition

ChEBI: 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine is a N-arylpiperazine.

Manufacturing Process

To a solution of 21 g of 1-(3':4'-methylenedioxybenzyl)-piperazine in solution in 300 cc of anhydrous xylene there were added 28 g of anhydrous potassium carbonate and then 11.3 g of 2-chloropyrimidine. The suspension was then heated for 9 hours at boiling point (130°C). After this time, the mixture was cooled and extracted several times with 10% hydrochloric acid. The acid solution obtained was washed with ether and then rendered alkaline with potassium carbonate; the oily product which was separated was extracted with chloroform and this, after drying with potassium carbonate and evaporation, gave an oily residue weighing 20 g. By dissolution in boiling ethanol and crystallization, 15 g of crystals melting at 96°C were recovered.

Therapeutic Function

Vasodilator

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine synthesis

Synthesis of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine from Piperonylic acid and 2-(1-Piperazinyl)pyrimidine

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Preparation Products And Raw materials

Raw materials

2-Chloropyrimidine 1-Piperonylpiperazine 1-Phenyl-1-propanol Piperonylic acid Piperonyl chloride

Piperonyl alcohol 2-(1-Piperazinyl)pyrimidine Piperonyl aldehyde

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Preparation Products

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Suppliers

Global( 178)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12460	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	16801	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Chemsigma International Co., Ltd.	+86-18136843612 +86-19951791336	info@chemsigma.com	China	968	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Chemsigma International Co., Ltd.	58

Uses and Side Effects of Vasodilator Piribedil
Pirbedil, also known as tasuda, Pronoran, Trivastal Retard, is clinically used as peripheral vascular and cerebral vasodilator....
Oct 17，2019

View Lastest Price from 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-12-23	2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 3605-01-4	US $50.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-09-19	2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 3605-01-4	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2021-07-27	2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine USP/EP/BP 3605-01-4	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
3605-01-4
US $50.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
3605-01-4
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine USP/EP/BP
3605-01-4
US $1.10 / g
99.9%
Dideu Industries Group Limited

3605-01-4(2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine)Related Search:

4-((4-(2-Pyrimidinyl)-1-piperazinyl)methyl)pyrocatechol hydrochloride hydrate (2:4:1) Piribedil-d8 Pirenoxine Entacapone CYCLAZOSIN HYDROCHLORIDE

Gabapentin PIRIBEDIL HYDROCHLORIDE 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 2-(4-[1,3-BENZODIOXOL-5-YLMETHYL]-1-PIPERAZINYL)PYRIMIDINE MALEATE SALT 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(3,4-DIMETHOXYPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE

2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-4-METHYL-7-(THIOPHEN-2-YL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]-7-[(E)-2-PHENYLETHENYL]-7,8-DIHYDRO-5(6H)-QUINAZOLINONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(FURAN-2-YL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(4-ISOPROPYLPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(2-CHLOROPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE

2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)PIPERAZIN-1-YL]-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(4-ISOPROPYLPHENYL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE

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Piribendyl 2-(4-(benzo[d][1,3]dioxol-5-ylMethyl)piperazin-1-yl)pyriMidine 1-(2-Pyrimidyl)-4-piperonylpiperazine PIRIBEDIL(FORR&DONLY0 PIRIBEDIOL ET-495 EU-4200 Trivastal Trivastan 2-(4-Piperonyl-1-piperazinyl)-Pyrimidine 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Pipidil Control Piribedil> Pyrimidine, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]- PIRIBEDIL USP/EP/BP 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine USP/EP/BP PIRIBEDIL Piribedi Pirbedil 3605-01-4 3605/1/4 622744 Isotope labelled API API