2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
![2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Structure](CAS/20150408/GIF/192718-06-2.gif)
- CAS No.
- 192718-06-2
- Chemical Name:
- 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
- Synonyms
- C527;C527 >=98% (HPLC);2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione;Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-;Inhibitor,C 527,DUBs,C527,Deubiquitinase,C-527,inhibit
- CBNumber:
- CB62719612
- Molecular Formula:
- C17H8FNO3
- Molecular Weight:
- 293.25
- MDL Number:
- MFCD01033540
- MOL File:
- 192718-06-2.mol
| Boiling point | 488.6±47.0 °C(Predicted) |
|---|---|
| Density | 1.433±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: soluble0.3mg/mL, clear (warmed) |
| pka | -4.21±0.20(Predicted) |
| form | powder |
| color | faint yellow to dark yellow |
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1008 | C527 ≥98% (HPLC) | 192718-06-2 | 5mg | $107 | 2022-05-15 | Buy |
| Cayman Chemical | 21771 | C527 ≥98% | 192718-06-2 | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 21771 | C527 ≥98% | 192718-06-2 | 10mg | $143 | 2024-03-01 | Buy |
| Cayman Chemical | 21771 | C527 ≥98% | 192718-06-2 | 25mg | $317 | 2024-03-01 | Buy |
| Cayman Chemical | 21771 | C527 ≥98% | 192718-06-2 | 50mg | $435 | 2024-03-01 | Buy |
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Chemical Properties,Uses,Production
Biological Activity
C527 is a pan-DUB enzyme inhibitor with high activity against USP1/UAF1 complex with IC50 value of 0.88 μM.
in vitro
Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC 50 of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro . However, the IC 50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents.
target
0.88 μM (USP1)
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Preparation Products And Raw materials
Raw materials
Preparation Products
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10026 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Zhengzhou GranLen pharmaceutical Technology Co., Ltd. | 0371-85513397 | info@granlen.com | China | 497 | 55 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |