ChemicalBook >> CAS DataBase List >>GSK-626616
GSK-626616
- CAS No.
- 1025821-33-3
- Chemical Name:
- GSK-626616
- Synonyms
- GSK-626616;(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone;4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-;GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase
- CBNumber:
- CB63303333
- Molecular Formula:
- C18H10Cl2N4OS
- Molecular Weight:
- 401.27
- MDL Number:
- MFCD31689261
- MOL File:
- 1025821-33-3.mol
Last updated:2023-06-30 15:45:59
| Melting point | 281 - 282oC |
|---|---|
| Boiling point | 574.8±60.0 °C(Predicted) |
| Density | 1.55±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator, under inert atmosphere |
| solubility | Chloroform (Slightly, Heated), Methanol (Slightly) |
| pka | -0.94±0.20(Predicted) |
| form | Solid |
| color | Pale Yellow to Light Yellow |
| FDA UNII | OKY0RM282V |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H335-H302-H315 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| NFPA 704 |
|
GSK-626616 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3355 | GSK626616 ≥98% (HPLC) | 1025821-33-3 | 5MG | $87 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3355 | GSK626616 ≥98% (HPLC) | 1025821-33-3 | 25MG | $350 | 2024-03-01 | Buy |
| Tocris | 6638 | GSK626616 ≥98%(HPLC) | 1025821-33-3 | 50 | $861 | 2021-12-16 | Buy |
| Tocris | 6638 | GSK626616 ≥98%(HPLC) | 1025821-33-3 | 10 | $205 | 2021-12-16 | Buy |
| TRC | G797853 | GSK-626616 | 1025821-33-3 | 10mg | $160 | 2021-12-16 | Buy |
GSK-626616 Chemical Properties,Uses,Production
Uses
GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.
storage
Store at +4°C
GSK-626616 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK-626616 Suppliers
Global( 36)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2986 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9833 | 58 |
GSK-626616
(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone
4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-
GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase
1025821-33-3