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GS967

GS967 Structure
GS967 structure
CAS No.
1262618-39-2
Chemical Name:
GS967
Synonyms
GS967;CS-1742;GS458967;GS-458967;GS 458967;GS967, >98%;GS967(GS-458967);GS-967;GS 967;GS-458967; GS 458967; GS458967;6-(4-(trifluoroMethoxy)phenyl)-3-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine;1,2,4-Triazolo[4,3-a]pyridine, 6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-
CBNumber:
CB72735521
Molecular Formula:
C14H7F6N3O
Molecular Weight:
347.22
MDL Number:
MFCD28385879
MOL File:
1262618-39-2.mol
Last updated:2023-05-21 10:59:17
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GS967 Properties

Density 1.52±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; ≥13.35 mg/mL in DMSO; ≥25.52 mg/mL in EtOH with ultrasonic
form solid
pka -0.41±0.50(Predicted)

GS967 price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18376 GS967 ≥98% 1262618-39-2 100mg $238 2024-03-01 Buy
Cayman Chemical 18376 GS967 ≥98% 1262618-39-2 10mg $88 2021-12-16 Buy
Cayman Chemical 18376 GS967 ≥98% 1262618-39-2 5mg $49 2021-12-16 Buy
Cayman Chemical 18376 GS967 ≥98% 1262618-39-2 25mg $93 2024-03-01 Buy
Cayman Chemical 18376 GS967 ≥98% 1262618-39-2 50mg $146 2024-03-01 Buy
Product number Packaging Price Buy
18376 100mg $238 Buy
18376 10mg $88 Buy
18376 5mg $49 Buy
18376 25mg $93 Buy
18376 50mg $146 Buy

GS967 Chemical Properties,Uses,Production

Uses

GS967, also known as GS-458967, is a highly selective late sodium channel current blocker. The selective inhibition of late INa with GS967 can exert antiarrhythmic effects by suppressing EAD- and DAD-mediated extrasystolic activity in PFs and PV and SVC sleeve preparations. Selective late INa inhibition with GS967 exerts potent protective effects against ischemia-induced depolarization and repolarization abnormalities in both atria and ventricles.

Biological Activity

gs967 is a potent, selective and novel inhibitor of cardiac late sodium current (late ina) with ic50=0.13 μm in ventricular myocytes and ic50=0.21μm in isolated hearts. [1]when na+ channels in myocytes fail to inactivate after opening, na+ influx continues throughout the ap plateau. the resulting na+ current (ina) is referred to as late ina. its magnitude is increased in many pathologic conditions, such as in the failing and/or ischemic heart, in the heart exposed to oxidative stress, and in hearts of patients with congenital long qt3 syndromes. [1]in rabbit isolated ventricular myocytes, inhibition of peak ina by gs967 is in a concentration- and voltage-dependent manner with minimal use-dependent, it also decreases the na+ and ca2+ overload. in rabbit-isolated heart, gs967 abolishes tdp induced by atx-ii or e-4031. [1]in anesthetized rabbit, gs967 reduces mapd90 but did not alter cardiac conduction time; it also prevents the induction of arrhythmic activity and tdp by clofilium and decreases the incidence of ischemia-induced arrhythmias. [1]

References

1. belardinelli l, liu g, smith-maxwell c et al. a novel, potent, and selective inhibitor ofcardiac late sodium current suppresses experimental arrhythmias. j pharmacol exp ther. 2013 jan;344(1):23-32.

GS967 Preparation Products And Raw materials

Raw materials

Preparation Products

GS967 Suppliers

Global( 80)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Wuhan Nutra Biotechnology Co.,Ltd 		+8617786394783 nutrabiotech@outlook.com China 300 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Wuhan Nutra Biotechnology Co.,Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aladdin Scientific 		58

View Lastest Price from GS967 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GS967 pictures 2021-10-08 GS967
1262618-39-2
 US $0.00-0.00 / g 1g 98% 100kgs Wuhan Nutra Biotechnology Co.,Ltd
6-(4-(trifluoroMethoxy)phenyl)-3-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine pictures 2019-09-06 6-(4-(trifluoroMethoxy)phenyl)-3-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine
1262618-39-2
 US $1.00 / KG 1KG 98% 20kg Career Henan Chemical Co
  • GS967 pictures
  • GS967
    1262618-39-2
  • US $0.00-0.00 / g
  • 98%
  • Wuhan Nutra Biotechnology Co.,Ltd

GS967 Spectrum

GS967(1262618-39-2)1HNMR

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GS967 6-(4-(trifluoroMethoxy)phenyl)-3-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine GS 458967 GS458967 GS-458967 GS-967;GS 967;GS-458967; GS 458967; GS458967 GS967(GS-458967) GS967, >98% CS-1742 1,2,4-Triazolo[4,3-a]pyridine, 6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)- 1262618-39-2 1262618-39-3 C14H7F6N3O Inhibitors