Suberohydroxamic acid
- CAS No.
- 38937-66-5
- Chemical Name:
- Suberohydroxamic acid
- Synonyms
- ODHA;SBHA;[PTYR705]-STAT3;STAT3 (PTYR705);SUBEROHYDROXAMIC ACID;SUBERIC BISHYDROXAMATE;SuberohydroxaMic acid 95%;SuberoylBis-hydroxamicAci;suberic bishydroxamic acid;SUBEROYL BISHYDROXAMIC ACID
- CBNumber:
- CB6673028
- Molecular Formula:
- C8H16N2O4
- Molecular Weight:
- 204.22
- MDL Number:
- MFCD00192455
- MOL File:
- 38937-66-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| HS Code | 2928009090 |
Suberohydroxamic acid price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 559418 | SBHA | 38937-66-5 | 100mg | $159 | 2024-03-01 | Buy |
| Sigma-Aldrich | 390585 | Suberohydroxamic acid 95% | 38937-66-5 | 1g | $77 | 2024-03-01 | Buy |
| Cayman Chemical | 10574 | Suberohydroxamic Acid ≥98% | 38937-66-5 | 100mg | $28 | 2024-03-01 | Buy |
| Cayman Chemical | 10574 | Suberohydroxamic Acid ≥98% | 38937-66-5 | 1g | $207 | 2024-03-01 | Buy |
| Cayman Chemical | 10574 | Suberohydroxamic Acid ≥98% | 38937-66-5 | 250mg | $63 | 2024-03-01 | Buy |
Suberohydroxamic acid Chemical Properties,Uses,Production
Description
Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.
Uses
Inhibits histone deacetylation.
Uses
Histone deacetylase inhibitor. A cell-permeable inhibitor of HDAC1 and HDAC3. Shown to suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells.
Definition
ChEBI: N,N'-dihydroxyoctanediamide is a hydroxamic acid.
Biological Activity
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.
Biochem/physiol Actions
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.
References
1. richon vm, emiliani s, verdin e et al. a class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. proc natl acad sci u s a. 1998 mar 17; 95(6):3003-7.2. zhang xd, gillespie sk, borrow jm, hersey p. the histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. mol cancer ther. 2004 apr; 3(4):425-35.
Suberohydroxamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Suberohydroxamic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | sales@kindchem.cn | China | 1227 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hebei Duling International Trade Co. LTD | +8617333973358 | sales01@hbduling.cn | China | 15568 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18451 | 58 |
| PNP Biotech Co. Ltd | +8618516098983 | sales@pnpbiotech.com | China | 1001 | 58 |
| Dalian Ruiying Technology Co., Ltd. | +86-0411-86907150 +86-15940963210 | 609262758@qq.com | China | 578 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from Suberohydroxamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-28 | Suberohydroxamic acid
38937-66-5
|
US $0.00 / KG | 25KG | 95% | Inquiry | PNP Biotech Co. Ltd | |
 |
2024-03-28 | N,N'-Dihydroxyoctanediamide
38937-66-5
|
US $0.00 / KG | 25KG | 95% | Inquiry | PNP Biotech Co. Ltd | |
 |
2020-01-10 | OCTANE-1,8-DIHYDROXAMIC ACID
38937-66-5
|
US $1.00 / g | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- Suberohydroxamic acid
38937-66-5
- US $0.00 / KG
- 95%
- PNP Biotech Co. Ltd
-
- N,N'-Dihydroxyoctanediamide
38937-66-5
- US $0.00 / KG
- 95%
- PNP Biotech Co. Ltd
-
- OCTANE-1,8-DIHYDROXAMIC ACID
38937-66-5
- US $1.00 / g
- 99.0%
- Career Henan Chemical Co