(R)-CPP
- CAS No.
- 126453-07-4
- Chemical Name:
- (R)-CPP
- Synonyms
- D-CPP;(R)-CCP;(R)-CPP;CPP (R)-;(R)CPP,(R) CPP;rac-(S*)-2-(2,4-Dichlorophenoxy)propanoic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propionic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid;(R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid;[3-[(2R)-2-Carboxypiperazin-4-yl]propyl]phosphonic acid
- CBNumber:
- CB6725314
- Molecular Formula:
- C8H17N2O5P
- Molecular Weight:
- 252.2
- MDL Number:
- MFCD00153786
- MOL File:
- 126453-07-4.mol
Boiling point | 546.7±60.0 °C(Predicted) |
---|---|
Density | 1.408±0.06 g/cm3(Predicted) |
storage temp. | Desiccate at RT |
solubility | Water: 100mM |
form | White crystalline powder. |
pka | 1.89±0.20(Predicted) |
Water Solubility | Soluble to 100 mM in water |
FDA UNII | A3QV2VT7SN |
(R)-CPP price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 21569 | (R)-CPP | 126453-07-4 | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 21569 | (R)-CPP | 126453-07-4 | 5mg | $169 | 2024-03-01 | Buy |
Cayman Chemical | 21569 | (R)-CPP | 126453-07-4 | 10mg | $319 | 2024-03-01 | Buy |
Cayman Chemical | 21569 | (R)-CPP | 126453-07-4 | 25mg | $704 | 2024-03-01 | Buy |
Tocris | 0247 | (R)-CPP | 126453-07-4 | 50 | $1574 | 2021-12-16 | Buy |
(R)-CPP Chemical Properties,Uses,Production
Description
(R)-CPP is an NMDA receptor antagonist (Ki = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with Ki values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 μmol/kg).
Uses
(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.
Biological Activity
Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively).
storage
Room temperature (desiccate)
(R)-CPP Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-CPP Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
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