sodium 5-(sec-butyl)-5-ethylbarbiturate
- CAS No.
- 143-81-7
- Chemical Name:
- sodium 5-(sec-butyl)-5-ethylbarbiturate
- Synonyms
- Prelital;Bubartal;Asturidon;Bubarbital sodium;Sodium butabarbital;Secbutobarbitone sodium;BUTABARBITAL SODIUM SALT;sodium 5-(sec-butyl)-5-ethylbarbiturate
- CBNumber:
- CB6925190
- Molecular Formula:
- C10H14N2Na2O3
- Molecular Weight:
- 256.2093
- MDL Number:
- MOL File:
- 143-81-7.mol
| Melting point | The free acid mp 165-168° |
|---|---|
| FDA UNII | 9WTD50I918 |
| EPA Substance Registry System | Butabarbital sodium (143-81-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| RIDADR | 3249 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
sodium 5-(sec-butyl)-5-ethylbarbiturate Chemical Properties,Uses,Production
Originator
Butisol sodium,Wallace Labs,USA
Uses
Sedative-hypnotic.
Manufacturing Process
5-sec-Butyl-5-ethylbarbituric acid was prepared from diethyl ester of malonic
acid in 3 steps. At the above malonic ester was reacted with C2H5Br and
sodium ethylate producing the diethyl ester of ethylmalonic acid, which after a
reaction with sodium ethylate and 2-butylbromide gave the ethyl-(2-butyl)-
malonic acid diethyl ester. The last one produced the 5-sec-butyl-5-ethylbarbituric
acid after a reaction with urea and sodium ethylate.
23 g sodium (1 mol) was dissolved in 300 ml alcohol. To this solution was
added a solution of 5-sec-butyl-5-ethyl-barbituric acid (1 mol) in 800 ml
alcohol. To a mixture was added 1000 ml benzene, which precipitated the
sodium salt of the barbituric acid (butabarbital sodium). The product was
filtered and dried.
brand name
Butabarb (Alpharma); Butalan (Lannett); Buticaps (Medpointe); Butisol Sodium (Medpointe); Sarisol (Halsey).
Therapeutic Function
Hypnotic