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neplanocin A

neplanocin A Structure
neplanocin A structure
CAS No.
72877-50-0
Chemical Name:
neplanocin A
Synonyms
A-11079B16;NephanocinA;neplanocin A;Neoplanocin A;3-Neplanocin A;(?)-Neplanocin A;Antibiotic A-11079B16;()-Neplanocin A Exclusive;(?)-Neplanocin A Exclusive;3-Cyclopentene-1,2-diol, 5-(6-amino-9H-purin-9-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-
CBNumber:
CB71397173
Molecular Formula:
C11H13N5O3
Molecular Weight:
263.25
MDL Number:
MFCD01735607
MOL File:
72877-50-0.mol
MSDS File:
SDS
Last updated:2023-05-26 08:28:50
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neplanocin A Properties

Melting point 214-216 °C (decomp)
Boiling point 632.6±65.0 °C(Predicted)
Density 1.91±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 0.2 mg/ml; DMSO: 3 mg/ml; PBS (pH 7.2): 0.3 mg/ml
form A crystalline solid
pka 13.43±0.70(Predicted)

neplanocin A price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10584 (?)-Neplanocin A ≥98% 72877-50-0 500μg $270 2024-03-01 Buy
Cayman Chemical 10584 (?)-Neplanocin A ≥98% 72877-50-0 1mg $510 2024-03-01 Buy
Cayman Chemical 10584 (?)-Neplanocin A ≥98% 72877-50-0 5mg $2096 2024-03-01 Buy
AK Scientific 4504CA NeplanocinA 72877-50-0 1mg $667 2021-12-16 Buy
Product number Packaging Price Buy
10584 500μg $270 Buy
10584 1mg $510 Buy
10584 5mg $2096 Buy
4504CA 1mg $667 Buy

neplanocin A Chemical Properties,Uses,Production

Description

S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (−)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM). It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity. Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID50 = 0.07 and 0.3 μg/ml, respectively).

neplanocin A synthesis

952418-11-0
72877-50-0
Synthesis of neplanocin A from Imidodicarbonic acid, 2-[9-[(3aS,4R,6aR)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3a,6a-dihydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]-9H-purin-6-yl]-, 1,3-bis(1,1-dimethylethyl) ester

neplanocin A Preparation Products And Raw materials

Raw materials

Imidodicarbonic acid, 2-[9-[(3aS,4R,6aR)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3a,6a-dihydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]-9H-purin-6-yl]-, 1,3-bis(1,1-dimethylethyl) ester

Preparation Products

neplanocin A Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19743 58
NewCan Biotech Limited 		+86-0571-86912261 +8613735419629 sales@newcanbio.com China 9980 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
Changzhou Xuanye Technology Co., Ltd 15195022192 279776773@qq.com China 2010 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Zhejiang Huida Biotech Co., LTD 0571-89903882 13626641628 jiangnan@huidabiotech.com China 3656 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Shanghai Universal Biotech Co.,Ltd 18768175414 gaojun@univ-bio.com China 24998 58
Zhejiang Huida Biotech Co., LTD 0571-0571-89903882 15990081639 sunshixuan@huidabiotech.com China 3705 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
BOC Sciences 		58
NewCan Biotech Limited 		58
Shanghai Hongye Biotechnology Co. Ltd 58
Changzhou Xuanye Technology Co., Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Zhejiang Huida Biotech Co., LTD 58
MedBioPharmaceutical Technology Inc 58
Shanghai Universal Biotech Co.,Ltd 58
Zhejiang Huida Biotech Co., LTD 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

72877-50-0(neplanocin A)Related Search:

neplanocin A
neplanocin A A-11079B16 Antibiotic A-11079B16 Neoplanocin A 3-Neplanocin A ()-Neplanocin A Exclusive 3-Cyclopentene-1,2-diol, 5-(6-amino-9H-purin-9-yl)-3-(hydroxymethyl)-, (1S,2R,5R)- (?)-Neplanocin A (?)-Neplanocin A Exclusive NephanocinA 72877-50-0