ChemicalBook >> CAS DataBase List >>7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate structure

CAS No.: 802904-66-1

Chemical Name:: 7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate

Synonyms: CS-1509;AZD1981;AZD1981, >=98%;AZD-1981;AZD 1981;Leuco-dcf diacetate;7'-Dichlorofluorescein diacetate;2-[4-acetamido-3-(4-chlorophenyl)sulfanyl-2-methylindol-1-yl]acetic acid;2-(4-acetamido-3-(4-chlorophenylthio)-2-methyl-1H-indol-1-yl)acetic acid;4-(Acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid;1H-Indole-1-acetic acid, 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-

CBNumber:: CB72657113

Molecular Formula:: C19H17ClN2O3S

Molecular Weight:: 388.87

MDL Number:: MFCD26936340

MOL File:: 802904-66-1.mol

Last updated:2023-06-08 09:03:09

Request For Quotation

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate Properties

Boiling point	676.8±55.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; insoluble in EtOH; ≥19.8 mg/mL in DMSO
form	solid
pka	4.06±0.10(Predicted)
FDA UNII	2AD53WQ2CX

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

NFPA 704

	0
2		0

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	20763	AZD 1981 ≥98%	802904-66-1	1mg	$32	2024-03-01	Buy
Cayman Chemical	20763	AZD 1981 ≥98%	802904-66-1	5mg	$116	2024-03-01	Buy
Cayman Chemical	20763	AZD 1981 ≥98%	802904-66-1	10mg	$214	2024-03-01	Buy
Cayman Chemical	20763	AZD 1981 ≥98%	802904-66-1	25mg	$420	2024-03-01	Buy
TRC	A795140	AZD1981	802904-66-1	10mg	$1175	2021-12-16	Buy

Product number	Packaging	Price	Buy
20763	1mg	$32	Buy
20763	5mg	$116	Buy
20763	10mg	$214	Buy
20763	25mg	$420	Buy
A795140	10mg	$1175	Buy

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate Chemical Properties,Uses,Production

Uses

AZD 1981 is an orally available selective DP2 antagonist in the treatment of asthma.

Biological Activity

azd1981 is a selective, orally bioavailable and potent antagonist of the chemoattractant receptor-homologous expressed on th2 lymphocytes receptor (crth2 or dp2) with an ic50 value of 4 nm [1].azd1981 has shown to inhibit eosinophil migration with a pic50 value of 7.6±0.1. azd1981 could block chemotaxis of dp2+ t-cell lines with a pic50 value of 7.5±0.1. azd1981 has been demonstrated to inhibit pgd2 binding to mouse, rat, rabbit, dog, guinea pig and human dp2. azd1981 could inhibit shape change induced by dp2 in dog and guinea pig granulocytes as well as in human eosinophils and basophils in blood [2].

References

[1] luker t1, bonnert r, brough s, cook ar, dickinson mr, dougall i, logan c, mohammed rt, paine s, sanganee hj, sargent c, schmidt ja,teague s, thom s. substituted indole-1-acetic acids as potent and selective crth2 antagonists-discovery of azd1981. bioorg med chem lett. 2011 nov 1;21(21):6288-92.
[2] schmidt ja1, bell fm, akam e, marshall c, dainty ia, heinemann a, dougall ig, bonnert rv, sargent ca. biochemical and pharmacological characterization of azd1981, an orally available selective dp2 antagonist in clinical development for asthma. br j pharmacol. 2013 apr;168(7):1626-38.

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate Preparation Products And Raw materials

Raw materials

Preparation Products

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate Suppliers

Global( 87)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28455	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
career henan chemical co	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

View Lastest Price from 7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-02	2-[4-acetamido-3-(4-chlorophenyl)sulfanyl-2-methylindol-1-yl]acetic acid 802904-66-1	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

2-[4-acetamido-3-(4-chlorophenyl)sulfanyl-2-methylindol-1-yl]acetic acid
802904-66-1
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

802904-66-1(7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate)Related Search:

Alisertib (MLN8237) 5-Azacytidine Pazopanib Hydrochloride Cediranib Temsirolimus

Pomalidomide

1of2

7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate AZD1981 1H-Indole-1-acetic acid, 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl- AZD1981, >=98% 4-(Acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid AZD-1981;AZD 1981 CS-1509 2-[4-acetamido-3-(4-chlorophenyl)sulfanyl-2-methylindol-1-yl]acetic acid 7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate USP/EP/BP 7'-Dichlorofluorescein diacetate Leuco-dcf diacetate 2-(4-acetamido-3-(4-chlorophenylthio)-2-methyl-1H-indol-1-yl)acetic acid 802904-66-1 Inhibitors