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(+)-AEROPLYSININ-1

(+)-AEROPLYSININ-1 Structure
(+)-AEROPLYSININ-1 structure
CAS No.
28656-91-9
Chemical Name:
(+)-AEROPLYSININ-1
Synonyms
NSC-170364;AEROPLYSININ;aeroplysinini;(+)-aeroplysinini;(+)-AEROPLYSININ-1;(+)shy-Aeroplysinin-1;Aeroplysinin (Aeroplysinin-1);AEROPLYSININ, APLYSINA AEROPHOBA;(+)-AEROPLYSININ-1, APLYSINA AEROPHOBA;4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr
CBNumber:
CB7286568
Molecular Formula:
C9H9Br2NO3
Molecular Weight:
338.98
MDL Number:
MFCD01745659
MOL File:
28656-91-9.mol
Last updated:2023-05-21 10:59:17
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(+)-AEROPLYSININ-1 Properties

Boiling point 479.6±45.0 °C(Predicted)
Density 2.01±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Methanol: Soluble
form A solid
pka 10.54±0.70(Predicted)

SAFETY

Risk and Safety Statements

HS Code  2941900000

(+)-AEROPLYSININ-1 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21498 (+)-Aeroplysinin-1 ≥95% 28656-91-9 100μg $117 2024-03-01 Buy
TRC A325708 (+)shy-Aeroplysinin-1 28656-91-9 250μg $85 2021-12-16 Buy
American Custom Chemicals Corporation API0024893 (+)-AEROPLYSININ-1 95.00% 28656-91-9 5MG $501.71 2021-12-16 Buy
Product number Packaging Price Buy
21498 100μg $117 Buy
A325708 250μg $85 Buy
API0024893 5MG $501.71 Buy

(+)-AEROPLYSININ-1 Chemical Properties,Uses,Production

Description

(+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities. (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM. It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay. It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.

Uses

(+)shy-Aeroplysinin-1 is a compound that is an inhibitor of EGFR kinase.

Definition

ChEBI: Aeroplysinin 1 is a tertiary alcohol.

(+)-AEROPLYSININ-1 Preparation Products And Raw materials

Raw materials

Preparation Products

(+)-AEROPLYSININ-1 Suppliers

Global( 47)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19743 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9901 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720 psaitong@jm-bio.com China 12308 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 29778 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
BOC Sciences 		58
Aladdin Scientific 		58
Shanghai T&W Pharmaceutical Co., Ltd. 58
Shanghai EFE Biological Technology Co., Ltd. 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58

28656-91-9((+)-AEROPLYSININ-1)Related Search:

(+)-Aeroplysinin-1, Aplysina areophoba,(+)-Aeroplysinin-1, Aplysina areophoba 3-HYDROXY-3-METHYLBUTYRONITRILE 5-Bromo-1-pentene 5-Hexenenitrile (R)-(-)-3-HYDROXYBUTYRONITRILE
(S)-3-Bromo-1,2-propanediol 5-BROMOVALERONITRILE (E)-2-BROMO-2-BUTEN-1-OL (+)-AEROPLYSININ-1 3-Bromo-3-buten-1-ol
1,3-DIBROMO-1-PROPENE 1-cyano-2-hydroxy-3-butene (S)-(+)-3-HYDROXYBUTYRONITRILE 5-Bromohex-5-enenitrile

1of3

(+)-aeroplysinini (1s-trans)-3,5-dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonit 4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr aeroplysinini AEROPLYSININ (+)-AEROPLYSININ-1 (+)-AEROPLYSININ-1, APLYSINA AEROPHOBA AEROPLYSININ, APLYSINA AEROPHOBA (1S)-1,6α-Dihydroxy-3,5-dibromo-4-methoxy-2,4-cyclohexadiene-1α-acetonitrile [1S,6R,(+)]-3,5-Dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonitrile NSC-170364 (1R)-1,6β-Dihydroxy-3,5-dibromo-4-methoxy-2,4-cyclohexadiene-1β-acetonitrile (1R)-3,5-Dibromo-1α,6β-dihydroxy-4-methoxy-2,4-cyclohexadiene-1β-acetonitrile Aeroplysinin (Aeroplysinin-1) (+)shy-Aeroplysinin-1 2,4-Cyclohexadiene-1-acetonitrile, 3,5-dibromo-1,6-dihydroxy-4-methoxy-, (1S,6R)- 28656-91-9 C9H9Br2NO3