N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
- CAS No.
- 210110-90-0
- Chemical Name:
- N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
- Synonyms
- NB-DNJ, HCL;Miglustat HCl;(2R,3R,4R,5S)-;N-BUTYL-DNJ, HCL;NB-DNJ hydrochloride;OGT918 hydrochloride;Zavesca hydrochloride;Miglustat HCl (OGT-918;Miglustat, Hydrochloride;N-BUTYLDEOXYNOJIRIMYCIN HCL
- CBNumber:
- CB7328886
- Molecular Formula:
- C10H22ClNO4
- Molecular Weight:
- 255.74
- MDL Number:
- MFCD00269940
- MOL File:
- 210110-90-0.mol
| Melting point | 169-172°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml) |
| form | White to off-white solid. |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| HS Code | 2933399990 |
N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21065 | N-Butyldeoxynojirimycin (hydrochloride) ≥98% | 210110-90-0 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 21065 | N-Butyldeoxynojirimycin (hydrochloride) ≥98% | 210110-90-0 | 5mg | $98 | 2024-03-01 | Buy |
| Cayman Chemical | 21065 | N-Butyldeoxynojirimycin (hydrochloride) ≥98% | 210110-90-0 | 10mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 21065 | N-Butyldeoxynojirimycin (hydrochloride) ≥98% | 210110-90-0 | 25mg | $353 | 2024-03-01 | Buy |
| Tocris | 3117 | Miglustathydrochloride | 210110-90-0 | 10 | $227 | 2021-12-16 | Buy |
N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Miglustat HCl (210110-90-0) is an orally active ceramide-specific glycosyltransferase and α-glucosidase I and II inhibitor.1 Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II.2 Pharmacological chaperone for glucocerebrosidase degradation.3 Clinically useful agent for Gaucher disease type 1.4 Stabilizes neurological disorders in Niemann-Pick disease type C.5
Chemical Properties
White Crystals
Uses
An inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. N-Butyldeoxynojirimycin has recently been used to retard lipid storage in the central nervous system of an animal m odel of Tay-Sachs disease. 1-Deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.
storage
Desiccate at -20°C
References
1) Platt et al. (1994), N-butyldeoxynojirimycin is a novel inhibitor if glycolipid biosynthesis; J. Biol. Chem., 269 8362 2) Noel et al. (2008), Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis; J. Pharmacol. Exp. Ther., 325 1016 3) Abian et al. (2011), Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase; Mol. Pharm., 8 2390 4) Serratrice et al. (2015), Switching from imiglucerase to miglustat for the treatment of French patients with Gaucher disease type 1: a case series; J. Med. Case Rep., 9 146 5) Karimzadeh (2013), Effects of miglustat on stabilization of neurological disorder in niemann-pick disease type C: Iranian pediatric case series; J. Child Neurol., 28 1599
N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 3001 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9978 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323967 +86-18015559028 | sales1@artkmedchem.com | China | 39009 | 58 |
View Lastest Price from N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-25 | N-Butyldeoxynojirimycin Hydrochloride
210110-90-0
|
US $10.00 / kg | 1kg | 99.912% | 10ton | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- N-Butyldeoxynojirimycin Hydrochloride
210110-90-0
- US $10.00 / kg
- 99.912%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
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