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(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one structure

CAS No.: 1971920-73-6

Chemical Name:: (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one

Synonyms: PRN-2246;SAR442168;Tolebrutinib;Tolebrutinib, SAR442168;Tolebrutinib/SAR442168/PRN2246;(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-;(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one;Tolebrutinib, (R)-1-(1-Acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one;(R,E)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-(penta-2,4-dien-2-yloxy)phenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one;2H-Imidazo[4,5-c]pyridin-2-one, 4-amino-1,3-dihydro-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)-

CBNumber:: CB73336057

Molecular Formula:: C26H25N5O3

Molecular Weight:: 455.51

MDL Number:: MFCD32710277

MOL File:: 1971920-73-6.mol

Last updated:2024-03-28 17:11:29

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(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Properties

Boiling point	698.1±65.0 °C(Predicted)
Density	1.334±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (219.53 mM; Need ultrasonic)
pka	7.03±0.20(Predicted)
FDA UNII	8CZ82ZYY9X

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0119132	Tolebrutinib 98.96%	1971920-73-6	5mg	$400	2021-12-16	Buy
ChemScene	CS-0119132	Tolebrutinib 98.96%	1971920-73-6	10mg	$680	2021-12-16	Buy
ChemScene	CS-0119132	Tolebrutinib 98.96%	1971920-73-6	50mg	$1950	2021-12-16	Buy
ChemScene	CS-0119132	Tolebrutinib 98.96%	1971920-73-6	100mg	$2900	2021-12-16	Buy
Chemenu	CM330008	4-amino-3-(4-phenoxyphenyl)-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]imidazo[4,5-c]pyridin-2-one 95%+	1971920-73-6	1g	$2742	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0119132	5mg	$400	Buy
CS-0119132	10mg	$680	Buy
CS-0119132	50mg	$1950	Buy
CS-0119132	100mg	$2900	Buy
CM330008	1g	$2742	Buy

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Chemical Properties,Uses,Production

Uses

Tolebrutinib is a drug candidate; used in preparation of Dihydroimidazopyridine derivatives for treatment of Bruton''s tyrosine kinase related diseases.

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Suppliers

Global( 47)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18224	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4022	58
Changzhou Guiding Bio-Tech. Co.,Ltd.	+86-519-519-86686860 +8618795626222	ning@guiding-bio.com	China	299	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	+8618235132063	sales@tihondan.com	China	3725	58
Suzhou ARTK Medchem Co., Ltd.	+86-512-68323967 +86-18015559028	sales1@artkmedchem.com	China	39009	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4604	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	58
Changzhou Guiding Bio-Tech. Co.,Ltd.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	58
Suzhou ARTK Medchem Co., Ltd.	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58

View Lastest Price from (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-03-29	(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)- 1971920-73-6	US $8.00-1.00 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-
1971920-73-6
US $8.00-1.00 / kg
99%
Henan Fengda Chemical Co., Ltd

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Tolebrutinib, (R)-1-(1-Acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one (R,E)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-(penta-2,4-dien-2-yloxy)phenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Tolebrutinib 2H-Imidazo[4,5-c]pyridin-2-one, 4-amino-1,3-dihydro-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)- SAR442168 PRN-2246 multiple,PRN 2246,SAR-442168,inhibit,Bruton tyrosine kinase,Tolebrutinib,sclerosis,Bruton,kinase,SAR 442168,tyrosine,Inhibitor,Btk,PRN-2246 Tolebrutinib, SAR442168 (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)- Tolebrutinib/SAR442168/PRN2246 1971920-73-6