(+)METHAMPHETAMINE HYDROCHLORIDE
- CAS No.
- 51-57-0
- Chemical Name:
- (+)METHAMPHETAMINE HYDROCHLORIDE
- Synonyms
- desoxyn;adipex;deofed;destim;dextim;doxyfed;gerovit;isophen;syndrox;dexoval
- CBNumber:
- CB7717701
- Molecular Formula:
- C10H16ClN
- Molecular Weight:
- 185.69
- MDL Number:
- MFCD00056130
- MOL File:
- 51-57-0.mol
| Melting point | 166-168?C |
|---|---|
| alpha | D25 +14 to +20° |
| Flash point | 9°C |
| storage temp. | Controlled Substance, -20°C Freezer |
| FDA UNII | 997F43Z9CV |
| EPA Substance Registry System | Methamphetamine hydrochloride (51-57-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02, GHS06, GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H301+H311+H331-H370 |
| Precautionary statements | P210-P280-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235 |
| Hazard Codes | T,F |
| Risk Statements | 25-39/23/24/25-23/24/25-11 |
| Safety Statements | 45-36/37-16 |
| RIDADR | 3249 |
| WGK Germany | 2 |
| RTECS | SH5455000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2939710000 |
| Toxicity | LD50 i.p. in mice: 70 mg/kg (Lands) |
(+)METHAMPHETAMINE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
(+)-Methamphetamine (Item No. 13997) is an analytical reference material categorized as an amphetamine. It is the more physiologically active isomer of (±)-methamphetamine and is both neurotoxic and frequently abused. Methamphetamine is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Chemical Properties
Off-White Solid
Originator
Desoxyn ,Abbott Laboratories
Uses
A CNS stimulant. Anorexic. In attention deficit disorder with hyperactivity. Controlled substance (stimulant).
Definition
ChEBI: A hydrochloride having methamphetamine as the base component.
Manufacturing Process
2 Methods of prepearing of methamphetamine:
1. (-)-Ephedrin was reduced by hydrogenesation with hydrogen in the presence of Pt-C catalyst to give the (+)-N-α-dimethylphenethylamine (methamphetamine), melting point 172°-174°C.
2. Methamphetamine was obtained by the methylation of
phenylisopropylamine.
To give methamphetamine hydrochloride the base methamphetamine was
treated by eqimolar quantity of hydrochloric acid.
Therapeutic Function
Sympathomimetic, Central stimulant
General Description
Methamphetamine, (+)-1-phenyl-2-methylaminopropanehydrochloride desoxyephedrine hydrochloride (Desoxyn), isthe N-methyl analog of dextroamphetamine. It has moremarked central and less peripheral action than dextroamphetamine.It has a very high abuse potential, and by the intravenousroute, its salts are known as “speed.” The overallabuse problem presented by the drug is a national disaster.Medicinally acceptable uses of methamphetamine are analogousto those of dextroamphetamine.
Biochem/physiol Actions
Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.
Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits toxic fumes of NOx and HCl. See also BENZEDRINE and various amphetamines.
(+)METHAMPHETAMINE HYDROCHLORIDE Preparation Products And Raw materials
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