AMBUPHYLLINE
- CAS No.
- 5634-34-4
- Chemical Name:
- AMBUPHYLLINE
- Synonyms
- Bufylline;Busylline;AMBUPHYLLINE;THEOPHYLLINE (AMBUPHYLLINE);Theophylline-?aminoisobutanol;THEOPHYLLINE-2-AMINOISOBUTANOL;1,3-Dimethyl-7H-purine-2,6-dione 2-amin;2-amino-2-methylpropan-1-ol,1,3-dimethyl-7H-purine-2,6-dione;1,3-Dimethyl-7H-purine-2,6-dione 2-amino-2-methylpropan-1-ol;3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, compound with 2-amino-2-methylpropan-1-ol (1:1)
- CBNumber:
- CB7838718
- Molecular Formula:
- C11H18N5O3
- Molecular Weight:
- 268.29232
- MDL Number:
- MFCD00215846
- MOL File:
- 5634-34-4.mol
- MSDS File:
- SDS
| Melting point | 254-256° |
|---|---|
| FDA UNII | VOU5V0B772 |
| ATC code | R03DA10 |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 i.v. in rabbits: 163 mg/kg; orally in mice: 600 mg/kg, (Thompson, Warren) |
|---|
AMBUPHYLLINE Chemical Properties,Uses,Production
Originator
Butaphyllamine,Merrell Dow,US,1944
Uses
Diuretic; relaxant (smooth muscle).
Manufacturing Process
Equimolecular proportions of theophylline and 2-amino-2-methyl-1-propanol are dissolved in water and the water is evaporated until crystallization is almost complete. The crystals are filtered off and dried. The product has a melting point of 254-256°C, softening at 245°C. It has a water solubility of about 55%. It may be compounded in the form of tablets, for oral administration, or may be prepared in solution for distribution in ampoules. For the manufacture of solutions for packaging in ampoules, it is more convenient to simply dissolve the theophylline and the butanolamine in water, without going through the intermediate step of separating the crystalline salt.
brand name
Butaphyllamine (Marion Merrell Dow).
Therapeutic Function
Diuretic, Smooth muscle relaxant
AMBUPHYLLINE Preparation Products And Raw materials
AMBUPHYLLINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Dr. J. Pharmachem (India) | +91 20 24332987 | info@jpharmachem.com | India | 97 | 55 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 31163 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-63373950 15353716720 | 1052@dideu.com | China | 10011 | 58 |