Nefazodone hydrochloride

Nefazodone hydrochloride Properties

Melting point	186-188°C
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO: ~11 mg/mL at 60 °C
form	solid
color	white
λmax	248nm(MeOH)(lit.)
Merck	14,6438
CAS DataBase Reference	82752-99-6(CAS DataBase Reference)
FDA UNII	27X63J94GR

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Safety Statements	22-24/25
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS	XZ5483009
HS Code	2933595960

Nefazodone hydrochloride price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N5536	Nefazodone hydrochloride ≥98% (HPLC), solid	82752-99-6	10mg	$168	2024-03-01	Buy
Sigma-Aldrich	5.08148	Nefazodone Hydrochloride - CAS 82752-99-6 - Calbiochem	82752-99-6	10mg	$155	2024-03-01	Buy
Sigma-Aldrich	1457902	Nefazodone hydrochloride United States Pharmacopeia (USP) Reference Standard	82752-99-6	200mg	$1040	2024-03-01	Buy
TCI Chemical	N1030	Nefazodone Hydrochloride >98.0%(HPLC)(T)	82752-99-6	200mg	$32	2024-03-01	Buy
TCI Chemical	N1030	Nefazodone Hydrochloride >98.0%(HPLC)(T)	82752-99-6	1g	$89	2024-03-01	Buy

Product number	Packaging	Price	Buy
N5536	10mg	$168	Buy
5.08148	10mg	$155	Buy
1457902	200mg	$1040	Buy
N1030	200mg	$32	Buy
N1030	1g	$89	Buy

Nefazodone hydrochloride Chemical Properties,Uses,Production

Description

Nefazodone, a second generation trazodone type antidepressant, was launched in Canada. Nefazodone acts as both a potent 5-HT₂ receptor antagonist and as a serotonin (5-HT) reuptake inhibitor. This combination effect appears to enhance 5-HT_IA-mediated neurotransmission. Distinct from the first generation agents such as tricyclic antidepressants, nefazodone has very selective serotonergic effects with negligible affinity for cholinergic and histamine receptors, and low affinity for a₁ -adrenergic receptors. Therefore, it has a superior toxicity profile that does not produce agitation, insomnia, and lacks cardiac side effects.

Chemical Properties

White Solid

Originator

Bristol-Myers Squibb (U.S.A.)

Uses

An antidepressant acts by modifying serotonin transmission. Mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor

Uses

A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.

Definition

ChEBI: Nefazodone hydrochloride is a hydrochloride. It contains a nefazodone.

Manufacturing Process

Manufacturing process for Moxifloxacin hydrochloride includes these steps as follows: 1. synthesis of 1-(3-Chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride, 1-(3-Chlorophenyl)-4-(hydrazinopropyl)piperazine. 2.Phenoxypropionic acid (249.0 g, 1.50 mol) is dissolved in four equivalents of thionyl chloride (438.0 ml, 6.0 mol) and heated to reflux until the HCl evolution has ceased. The solution is then cooled to room temperature and concentrated under reduced pressure to give 281.0 g (100% yield) of phenoxypropionyl chloride as a brown oil which solidifies on cooling 3.Phenoxypropionyl chloride (9.23 g, 0.05 mol) is dissolved in 100 ml acetone and cooled with an ice bath as sodium azide (3.6 g, 0.055 mol) in 10 ml water is added dropwise. After addition is completed, the reaction mixture is warmed to room temperature and stirred for 30 minutes. The solution is decanted and concentrated. The residue is dissolved in 100 ml ether and washed with saturated sodium bicarbonate and brine. The organic phase is separated, dried (MgSO4) and concentrated to give 6.52 g (68.0% yield) of phenoxypropionyl azide as a yellow oil which solidifies on cooling. 4.Synthesis of Ethyl phenoxypropionate, Phenoxypropionyl hydrazide, Phenoxyethyl isocyanate, 2-3-(4-[3-Chlorophenyl]-1-piperazinyl)propyl]-4-(2-phenoxyethyl)- semicarbazide), and 2-[3-4-(3-Chlorophenyl)-1-piperazinyl]-propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one monohydrochloride (Nefazodone monohydrochloride).

brand name

Serzone (Bristol-Myers Squibb).

Therapeutic Function

Antidepressant

General Description

Nefazodone, formerly sold under the brand names Serzone, Dutonin, and Nefadar, is an antidepressant that has been discontinued due to the incidence of severe liver damage. This certified Snap-N-Spike^; solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.

Biological Activity

Serotonin 5-HT 2A receptor antagonist (K i = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC 50 values are 290 and 300 nM respectively). Displays no activity at 5-HT 1B and 5-HT 1D receptors. Active in models predictive of antidepressant potential.

Biochem/physiol Actions

Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.

Nefazodone hydrochloride Preparation Products And Raw materials

Raw materials

Thionyl chloride Triethyl orthopropionate Α-PHENOXYPROPIONIC ACID HYDRAZINE Sodium nitrite

1-(3-Chlorphenyl)piperazine

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Preparation Products

Nefazodone hydrochloride Suppliers

Global( 206)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81148696 +8615536356810	1047@dideu.com	China	2237	58
AFINE CHEMICALS LIMITED	0571-85134551 18958018566;	info@afinechem.com	China	15377	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9427	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Hong Kong Excellence Biotechnology Co., Ltd.	+86-86-18838029171 +8618126314766	ada@sh-teruiop.com	China	893	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Healthchem co.,ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hong Kong Excellence Biotechnology Co., Ltd.	58

View Lastest Price from Nefazodone hydrochloride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-04-27	Nefazodone hydrochloride 82752-99-6	US $0.10 / KG	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	Nefazodone hydrochloride 82752-99-6	US $1.00 / kg	1kg	98%	100KG	Career Henan Chemical Co

Nefazodone hydrochloride
82752-99-6
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

Nefazodone hydrochloride
82752-99-6
US $1.00 / kg
98%
Career Henan Chemical Co

82752-99-6(Nefazodone hydrochloride)Related Search:

Naphazoline hydrochloride Topotecan hydrochloride Furazolidone Naphazoline Triadimefon

Trazodone Nefazodone Related Compound B,Nefazodone Related Compound B NEFAZODONE,Nefazodone base,Nefazodone (base and/or unspecified salts),NEFAZODONE,Nefazodone base,Nefazodone (base and/or unspecified salts) 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Nefazodone Related Compound A,Nefazodone Related Compound A

HYDROXY NEFAZODONE HCL,HYDROXY NEFAZODONE HCL Nefazodone hydrochloride NEFAZODONE , TRAZODONE,NEFAZODONE , TRAZODONE HYDROXY NEFAZODONE-D5 HCL,HYDROXY NEFAZODONE-D5 HCL 5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazole-3-one (intermediate of nefazodone hcl)

Nefazodone Hcl

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NEFAZODONE-D5 HCL 3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride Nefazodone HCl Nefazodone hydrochloride NEFAZODONE BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride 2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride Nefazodone Hydrochloride (200 mg) 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one BMY 13754-1 Serazone Nefazodone hydrochloride API 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one hydrochloride Nefazodone hydrochlo 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)- >=98% (HPLC) 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4 )-trans-4-(3-cyanophenyl)pyrrolidine-3-carboxylic acid &ge 3-[(3-Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate &ge Na-Fmoc-Nb-(N-Boc-amino-oxyacetyl)-L-2,3-diaminopropionic acid &ge Fmoc-1-amino-4-oxo-cyclohexane carboxylic acid &ge 8-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione &ge Fmoc-D-2-amino-4-bromo-4-pentenoic acid &ge 2-Amino-5-(4-fluorophenyl)-1,3,4-thiadiazole &ge 3-(4-Methoxyphenyl)pyrazole &ge Boc-N-ethyl glycine &ge Boc-D-a-aminobutyric acid &ge Na-Fmoc-Ne-Z-L-lysine &ge (1,2-Dibromoethyl)benzene &ge Na-Acetyl-L-ornithine &ge Na-Acetyl-D-tryptophan &ge 5,6-Dimethoxyindole &ge Z-L-serine amide &ge TFA &ge Gly-OBg· Boc-4-iodo-L-phenylalanine &ge Boc-S-tert-butyl-L-cysteine dicyclohexylammonium salt &ge D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid &ge (3R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid tert-butyl ester hydrochloride &ge 4-Acetamido-2-methylbenzoic acid &ge Methyl 2,4-dioxo-4-(2-thienyl)butanoate &ge 3-(4-Fluorophenyl)-1H-pyrazole-5-carbohydrazide &ge (3-Benzothienyl)-L-b-homoalanine hydrochloride &ge 2-(2H-Tetrazol-5-yl)pyridine &ge (S)-Fmoc-3-amino-2-benzyl-propionic acid &ge 7-Methoxy-1H-indole-3-carbaldehyde &ge 2-Chloro-6-methyl-4-(trifluoromethyl)pyridine &ge 5-Amino-2-methylpyridine &ge Ethyl 3-Amino-3-ethoxyacrylate hydrochloride &ge Fmoc-(4-aminomethyl) benzoic acid &ge Fmoc-3,4-dichloro-L-b-homophenylalanine &ge 1,3-Diacetylindole &ge Fmoc-3-nitro-D-phenylalanine &ge 4-Amino-D-phenylalanine hydrochloride &ge Fmoc-(R)-4-aminopimelic acid 1-tert-butyl ester &ge 5-Azacytidine &ge 1-(2-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbohydrazide &ge 5-(4-Bromophenyl)thiophene-2-carboxylic acid &ge