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2'-O-(2-Methoxyethyl)-5-methyluridine

2'-O-(2-Methoxyethyl)-5-methyluridine structure

CAS No.: 163759-49-7

Chemical Name:: 2'-O-(2-Methoxyethyl)-5-methyluridine

Synonyms: MOE-mrU;2'-O-MOE-Tr;2'-MOE-5-Me-rU;5-Me-2'-O-MOE U;5-Me-2'-O-MOE U;5-Me-2'-O-MOE-Ur;2'-O-MOE-5-Me-rU;2'-MOE-5-Me-Uridine;5-Me-2'-O-MOE Uridine;2’-MOE-5-Methyluridine

CBNumber:: CB82510024

Molecular Formula:: C13H20N2O7

Molecular Weight:: 316.31

MDL Number:: MFCD02682964

MOL File:: 163759-49-7.mol

MSDS File:: SDS

Last updated:2023-11-28 11:20:42

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2'-O-(2-Methoxyethyl)-5-methyluridine Properties

Melting point	115.5-116.5 °C
Density	1.41
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form	Solid
pka	9.55±0.10(Predicted)
color	Off-White
Stability	Hygroscopic
InChI	InChI=1S/C13H20N2O7/c1-7-5-15(13(19)14-11(7)18)12-10(21-4-3-20-2)9(17)8(6-16)22-12/h5,8-10,12,16-17H,3-4,6H2,1-2H3,(H,14,18,19)/t8-,9-,10-,12-/m1/s1
InChIKey	NEVQCHBUJFYGQO-DNRKLUKYSA-N
SMILES	OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1O
FDA UNII	9Q36I4D9VB

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H320-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

2'-O-(2-Methoxyethyl)-5-methyluridine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M304495	2''-O-(2-Methoxyethyl)-5-methyl-uridine	163759-49-7	100mg	$50	2021-12-16	Buy
TRC	M304495	2''-O-(2-Methoxyethyl)-5-methyl-uridine	163759-49-7	250mg	$110	2021-12-16	Buy
Biosynth Carbosynth	NM57538	2'-O-(2-Methoxyethyl)-5-methyluridine	163759-49-7	500mg	$150	2021-12-16	Buy
Biosynth Carbosynth	NM57538	2'-O-(2-Methoxyethyl)-5-methyluridine	163759-49-7	1g	$250	2021-12-16	Buy
Biosynth Carbosynth	NM57538	2'-O-(2-Methoxyethyl)-5-methyluridine	163759-49-7	250mg	$85	2021-12-16	Buy

Product number	Packaging	Price	Buy
M304495	100mg	$50	Buy
M304495	250mg	$110	Buy
NM57538	500mg	$150	Buy
NM57538	1g	$250	Buy
NM57538	250mg	$85	Buy

2'-O-(2-Methoxyethyl)-5-methyluridine Chemical Properties,Uses,Production

Uses

2'-O-(2-Methoxyethyl)-5-methyluridine is a protected uridine derivative (U829910) and nucleoside used in the preparation of synthetic nucleic acids.

Application

2'-O-(2-Methoxyethyl)-5-methyluridine (2'-MOE-5-Methyluridine) is a uridine nucleoside that is a combination of amidite with 5-methyluridine. 2'-MOE-5-Methyluridine is an intermediate in the synthesis of oligonucleotides, which are synthesized from phosphoramidites. Its analog 5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine is a potent compound used in research of RNA viruses, particularly hepatitis C virus and picornaviruses.

Synthesis

2,2'-Anhydro-5-methyluridine (195 g, 0.81 M), tris(2-methoxyethyl)borate (231 g, 0.98 M) and 2-methoxyethanol (1.2 L) were added to a 2 L stainless steel pressure vessel and placed in a pre-heated oil bath at 160°C. After heating for 48 hours at 155-160°C, the vessel was opened and the solution evaporated to dryness and triturated with methanol (200 mL). The residue was suspended in hot acetone (1 L). The insoluble salts were filtered, washed with acetone (150 mL) and the filtrate evaporated. The residue (280 g) was dissolved in CH3CN (600 mL) and evaporated. A silica gel column (3 kg) was packed in CH2Cl2/ acetone/methanol (20:5:3) containing 0.5% Et3NH. The residue was dissolved in CH2Cl2 (250 mL) and adsorbed onto silica (150 g) prior to loading onto the column. The product was eluted with the packing solvent to give product. Yield 160 g, 63%.

2'-O-(2-Methoxyethyl)-5-methyluridine synthesis

Synthesis of 2'-O-(2-Methoxyethyl)-5-methyluridine from 2,2'-Anhydro-5-methyluridine and 2-Methoxyethanol

2'-O-(2-Methoxyethyl)-5-methyluridine Preparation Products And Raw materials

Raw materials

tris(2-methoxyethyl) orthoborate 2,2'-Anhydro-5-methyluridine 2-Methoxyethanol

Preparation Products

2'-O-(2-Methoxyethyl)-5-methyluridine Suppliers

Global( 101)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7019	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9641	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58

Supplier	Advantage
Yunbio Tech Co.,Ltd.	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Nanjing Baifuli Technology Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
Antai Fine Chemical Technology Co.,Limited	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
SIMAGCHEM CORP	58

View Lastest Price from 2'-O-(2-Methoxyethyl)-5-methyluridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-02-06	2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7	US $0.00-0.00 / KG	1KG	99%	200KG per month	Yunbio Tech Co.,Ltd.
2023-04-04	2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7	US $0.00-0.00 / kg	1kg	98%	500kg per month	Zhejiang Hengkang Pharmaceutical Co., Ltd.
2022-09-27	2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2'-O-(2-Methoxyethyl)-5-methyluridine
163759-49-7
US $0.00-0.00 / KG
99%
Yunbio Tech Co.,Ltd.

2'-O-(2-Methoxyethyl)-5-methyluridine
163759-49-7
US $0.00-0.00 / kg
98%
Zhejiang Hengkang Pharmaceutical Co., Ltd.

2'-O-(2-Methoxyethyl)-5-methyluridine
163759-49-7
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

163759-49-7(2'-O-(2-Methoxyethyl)-5-methyluridine)Related Search:

2'-O-Methylcytidine DMT-2μ-O-Me-rG(ib) amidite 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-2′Fluoro-dU Phosphoramidite 2'-O-MOE-A(Bz)-3'-phosphoramidite

N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite Dmt-2'-f-dc(ac) amidite 2'-O-Methyladenosine 2'-O-(2-Methoxyethyl)cytidine

2'-O-Methylguanosine 2'-O-(2-Methoxyethyl)uridine DMT-2'-O-MOE-rU Phosphoramidite 2'-O-MOE-ADENOSINE 2'-OMe-ibu-G Phosphoramidite

2'-O-(2-Methoxyethyl)guanosine

1of4

2'-O-(2-Methoxyethyl)-5-methyluridine 5-Me-2'-O-MOE U Uridine, 2'-O-(2-Methoxyethyl)-5-Methyl- 5-Me-2'-O-MOE Uridine 2'-O-(2-Methoxyethy)-5-methyluridine 2'-O-(2-Methoxyethyl)-5-Methyl-uridine, >97% 1-[4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]-5-METHYL-3H-PYRIMIDINE-2,4-DIONE 2'-O-MOE-5-Methyluridin 2'-O-MOE-Tr 2'-O-Methoxyethyl-thyminde 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 2'-MOE-5-Me-Uridine 2’-MOE-5-Methyluridine 5-Me-2'-O-MOE-Ur MOE-mrU 2'-MOE-5-Me-rU 2'-O-Methoxyethyl-5-methyluridine 2'-O-MOE-5-Me-rU 2'-O-(2-Methoxyethyl)-5-methyluridine 2’-O-(2-Methoxyethy)-5-methyl uridine 5-Me-2'-O-MOE U 2'-MOE-5-Methyluridine 163759-49-7 Modified（deoxy）nucleoside