BAY-57-1293
- CAS No.
- 348086-71-5
- Chemical Name:
- BAY-57-1293
- Synonyms
- Pritelivir;N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide;CS-857;AIC316;BAY-57-1293;Pritelivir base;PRITELIVIR;AIC316;BAY571293(Pritelivir);Pritelivir,BAY-57-1293;PRITELIVIR; BAY-57-1293; AIC316
- CBNumber:
- CB82627368
- Molecular Formula:
- C18H18N4O3S2
- Molecular Weight:
- 402.49
- MDL Number:
- MFCD18633192
- MOL File:
- 348086-71-5.mol
- MSDS File:
- SDS
| Boiling point | 639.4±65.0 °C(Predicted) |
|---|---|
| Density | 1.396±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | insoluble in H2O; insoluble in EtOH; ≥13.9 mg/mL in DMSO |
| form | solid |
| pka | 9.31±0.60(Predicted) |
| FDA UNII | 07HQ1TJ4JE |
| NCI Drug Dictionary | pritelivir |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
BAY-57-1293 price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22129 | BAY 57-1293 ≥98% | 348086-71-5 | 5mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 22129 | BAY 57-1293 ≥98% | 348086-71-5 | 50mg | $160 | 2024-03-01 | Buy |
| Cayman Chemical | 22129 | BAY 57-1293 ≥98% | 348086-71-5 | 1mg | $25 | 2021-12-16 | Buy |
| Cayman Chemical | 22129 | BAY 57-1293 ≥98% | 348086-71-5 | 10mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 22129 | BAY 57-1293 ≥98% | 348086-71-5 | 25mg | $112 | 2024-03-01 | Buy |
BAY-57-1293 Chemical Properties,Uses,Production
Uses
BAY 57-1293 is a potent inhibitor of herpes simplex virus (HSV) that target the virus helicase primase complex.
Biological Activity
bay 57-1293 is a potent and safe inhibitor of hsv helicase-primase with ic50 value of 12nm [1].bay 57-1293 displays anti-herpes activity through inhibiting the helicase-primase and affecting the viral dna synthesis. in the in vitro viral replication assay, bay 57-1293 shows inhibition against hsv-1 f, hsv-2 g and acyclovir-resistant hsv-1 f mutant with ic50 value of 20nm. in the plaque reduction assay and the conventional cytopathogenicity assay, bay 57-1293 shows ic50 values of 0.01-0.02μm and 0.01-0.03μm, respectively. besides that, bay 57-1293 is active at an ic50 value of 10nm–30nm against all clinical isolates of hsv-1 and hsv-2. furthermore, bay 57-1293 is active in vivo. the oral administration of bay 57-1293 shows 10-fold more potent than valacyclovir in a murine model of disseminated herpes infection. in a rat lethal challenge model, bay 57-1293 exerts profound antiviral activity without toxic effects. [1, 2]
storage
Store at -20°C
References
[1] kleymann g, fischer r, betz u a k, et al. new helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. nature medicine, 2002, 8(4): 392-398.
[2] betz u a k, fischer r, kleymann g, et al. potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor bay 57-1293. antimicrobial agents and chemotherapy, 2002, 46(6): 1766-1772.
BAY-57-1293 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
View Lastest Price from BAY-57-1293 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-09-27 | BAY-57-1293
348086-71-5
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-07-10 | BAY-57-1293
348086-71-5
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- BAY-57-1293
348086-71-5
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- BAY-57-1293
348086-71-5
- US $7.00 / KG
- 99%
- Career Henan Chemical Co