2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
- CAS No.
- 54135-60-3
- Chemical Name:
- 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
- Synonyms
- M50054;2,2-METHYLENEBIS-(1,3-CYCLOHEXANEDIONE);2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE);2,2'-METHYLENE BIS CYCLOHEXANE-1,3-DIONE;1,3-Cyclohexanedione, 2,2'-methylenebis-;Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem;2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione;Apoptosis,Alopecia,Hepatitis,chemotherapy,Inhibitor,M50054,Caspase-3,Etoposide,Fas,M-50054,anti-Fas,M 50054,inhibit
- CBNumber:
- CB8363800
- Molecular Formula:
- C13H16O4
- Molecular Weight:
- 236.26
- MDL Number:
- MFCD00192291
- MOL File:
- 54135-60-3.mol
| Melting point | 132.5-133.5 °C |
|---|---|
| Boiling point | 461.2±40.0 °C(Predicted) |
| Density | 1.227±0.06 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | Soluble in DMSO or ethanol |
| form | Off-white solid |
| pka | 4.87±0.25(Predicted) |
| Sensitive | Light Sensitive |
| FDA UNII | NP899EA5D8 |
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R750778 | 2,2''-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) AldrichCPR | 54135-60-3 | 1G | $179 | 2024-03-01 | Buy |
| Sigma-Aldrich | 178488 | Apoptosis Inhibitor | 54135-60-3 | 10mg | $159 | 2024-03-01 | Buy |
| Alfa Aesar | J65036 | M50054 | 54135-60-3 | 10mg | $121 | 2021-12-16 | Buy |
| Cayman Chemical | 20810 | M50054 ≥98% | 54135-60-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20810 | M50054 ≥98% | 54135-60-3 | 5mg | $78 | 2024-03-01 | Buy |
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Chemical Properties,Uses,Production
Uses
A cell-permeable inhibitor of apoptosis induction. Inhibits caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml.
Definition
ChEBI: 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione is a beta-diketone.
Biological Activity
m50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1]in human fas-expressing wc8 cells, m50054 inhibited apoptosis by soluble human fas ligand in vitro cell death assay. m50054 inhibited the apoptotic u937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. m50054 inhibited apoptotic characters such as dna phosphatidylserine and fragmentation exposure in these cells. these anti-apoptotic effects were dependent on inhibition of caspase-3 activation. additionally, m50054 significantly inhibited anti-fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. alopecia (hair loss) symptoms were also significantly improved with topical treatment with m50054. m50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia. [1]
target
Caspase
References
tsuda t, ohmori y, muramatsu h et al. inhibitory effect of m50054, a novel inhibitor of apoptosis, on anti-fas-antibody-induced hepatitis and chemotherapy-induced alopecia.eur j pharmacol. 2001 dec 14;433(1):37-45.
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Preparation Products And Raw materials
Raw materials
Preparation Products
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| ApexBio Technology LLC | +1-832-696-8203 | info@apexbt.com | United States | 477 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4986 | 55 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |