ChemicalBook >> CAS DataBase List >>E-4031
E-4031
- CAS No.
- 113559-13-0
- Chemical Name:
- E-4031
- Synonyms
- E-4031;E4031 diHCl;E-4031 (hydrochloride);1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined;methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb;Inhibitor,anti-arrhythmic,Potassium Channel,E4031,E 4031,KcsA,inhibit,E-4031,hERG;N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL;N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride;N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid;N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
- CBNumber:
- CB8384065
- Molecular Formula:
- C21H33Cl2N3O5S
- Molecular Weight:
- 510.47
- MDL Number:
- MFCD00889193
- MOL File:
- 113559-13-0.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| storage temp. | -20°C |
|---|---|
| solubility | H2O: soluble |
| form | solid |
| color | off-white |
| Stability | Hygroscopic |
| FDA UNII | 814AT2BQO7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
E-4031 price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M5060 | E-4031 ≥98% (HPLC), lyophilized powder | 113559-13-0 | 0.1mg | $264 | 2024-03-01 | Buy |
| Sigma-Aldrich | M5060 | E-4031 ≥98% (HPLC), lyophilized powder | 113559-13-0 | 0.5mg | $458.4 | 2024-03-01 | Buy |
| Cayman Chemical | 15203 | E-4031 (hydrochloride) ≥98% | 113559-13-0 | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 15203 | E-4031 (hydrochloride) ≥98% | 113559-13-0 | 10mg | $143 | 2024-03-01 | Buy |
| Sigma-Aldrich | M5060 | E-4031 ≥98% (HPLC), solid | 113559-13-0 | 1mg | $1340 | 2024-03-01 | Buy |
E-4031 Chemical Properties,Uses,Production
Uses
E-4031 has been used as:
- human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
- IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
- IKr blocker in rat ventricular myocytes
Biological Activity
Selective blocker of hERG K + channels; inhibits the rapid delayed-rectifier K + current (I Kr ). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na + or Ca 2+ inward currents. Class III antiarrhythmic agent.
Biochem/physiol Actions
E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.
storage
Room temperature (desiccate)
E-4031 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 80)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Supplier | Advantage |
|---|---|
| Hangzhou FandaChem Co.,Ltd. | 55 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| BOC Sciences | 58 |
| career henan chemical co | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
| Alfa Chemistry | 58 |
| TargetMol Chemicals Inc. | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Aladdin Scientific | 58 |
| Amadis Chemical Company Limited | 58 |
113559-13-0(E-4031)Related Search:
N-Methylbenzylamine
N,N-DIETHYL-N-[2-(2-PYRIDYL)ETHYL]AMINE
4-BENZOYLPIPERIDINE HYDROCHLORIDE
Betahistine dihydrochloride
N-(4-ACETYL-PHENYL)-METHANESULFON-AMIDE
E-4031,E-4031 DIHYDROCHLORIDE
4-(4-PIPERIDINYLMETHYL)-BENZENAMINE
4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE
1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE
E-4031
1of4
1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined
methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb
E-4031
N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid
E-4031 (hydrochloride)
N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL
N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride
Inhibitor,anti-arrhythmic,Potassium Channel,E4031,E 4031,KcsA,inhibit,E-4031,hERG
E4031 diHCl
113559-13-0
C21H27N3O3S2HCl
Cell Biology
Cell Signaling and Neuroscience
Monovalent Ion Channels
Ion Channels
Potassium Channel Modulators
Voltage-gated Ion Channels
BioChemical
Potassium channel
Ion Channels