APRINDINE HCL
- CAS No.
- 33237-74-0
- Chemical Name:
- APRINDINE HCL
- Synonyms
- ms-5075;fiboran;aspenon;Fibocil;Amidonal;Aprindina;APRINDINE HCL;Compound 83846;APRINDINE HYDROCHLORIDE;APRINDINE HCL ISO 9001：2015 REACH
- CBNumber:
- CB8440044
- Molecular Formula:
- C22H31ClN2
- Molecular Weight:
- 358.95
- MDL Number:
- MFCD01698392
- MOL File:
- 33237-74-0.mol
- MSDS File:
- SDS
| Melting point | 120-121° |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: >10mg/mL |
| form | solid |
| color | Light Brown to Brown |
| Stability | Hygroscopic |
| FDA UNII | PB5EKT7Q2V |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| RTECS | TX7386000 |
APRINDINE HCL price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A7606 | Aprindine hydrochloride ≥98% (HPLC), solid | 33237-74-0 | 10mg | $188 | 2024-03-01 | Buy |
| Sigma-Aldrich | A7606 | Aprindine hydrochloride ≥98% (HPLC), solid | 33237-74-0 | 50mg | $736 | 2024-03-01 | Buy |
| Usbiological | 162668 | Aprindine Hydrochloride | 33237-74-0 | 50mg | $701 | 2021-12-16 | Buy |
| TRC | A729900 | Aprindine hydrochloride | 33237-74-0 | 250mg | $1295 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0025936 | APRINDINE HYDROCHLORIDE 95.00% | 33237-74-0 | 1MG | $597.89 | 2021-12-16 | Buy |
APRINDINE HCL Chemical Properties,Uses,Production
Originator
Amidonal,Madaus,W. Germany,1976
Uses
Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or intravenously in the treatment of ventricular arrhythmias of varying etiologies.
Definition
ChEBI: Aprindine hydrochloride is a member of indanes.
Manufacturing Process
104.6 g (0.5 mol) N-phenyl-2-aminoindane and 2.5 liters benzene are
introduced into a reaction vessel of 5 liters, under an atmosphere of nitrogen.
37 g (0.95 mol) sodium amide are added and the mixture is stirred during 3
hours at room temperature.
119.7 g (0.8 mol) of γ-chloropropyl diethylamine are then quickly added. After
agitation during 1 hour at room temperature, the reaction mixture is refluxed
and stirred under nitrogen during 21 hours. The mixture is then allowed to
cool and poured onto ice. The obtained aqueous phase is extracted by means
of 500 cm3 of benzene. The benzene extract is washed two times with 200
cm3 of water and the benzene is then evaporated.
The residue is treated with 500 cm3 of hydrochloric acid (2 N). The obtained
solution is evaporated to dryness and the oily residue is recrystallized from
ethanol. 176.9 g (yield 89.4%) of dihydrochloride of N-phenyl-Ndiethylaminopropyl-
2-aminoindane are obtained, MP 208° to 210°C.
The dihydrochloride is converted into monohydrochloride by dissolving 26.36 g
(0.066 mol) of dihydrochloride into 158 cm3 of water, adding drop by drop a
suitable amount (0.066 mol) of caustic soda (1 N), evaporating the aqueous
solution to dryness, drying by means of benzene, filtering the formed sodium
chloride (3.8 g) and crystallizing the cooled obtained benzene solution. 22.6 g
(95%) of monohydrochloride are obtained, MP 120° to 121°C.
brand name
Fibocil (Lilly).
Therapeutic Function
Antiarrhythmic
APRINDINE HCL Preparation Products And Raw materials
APRINDINE HCL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28149 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50002 | 58 |
| Tianjin central pharmaceutical co., LTD. | 4006010268 | China | 15 | 60 | |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 021-61259108 18621169109 | market03@meryer.com | China | 40240 | 62 |
| Wuhan DKY Technology Co.,Ltd. | 27-81302488 18007166089 | info@dkybpc.com | China | 2024 | 58 |
| Boen pharm | 86 512-62572107 62962707 | China | 800 | 58 |
View Lastest Price from APRINDINE HCL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-08-23 | APRINDINE HCL
33237-74-0
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- APRINDINE HCL
33237-74-0
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited