ChemicalBook >> CAS DataBase List >>SR 12813
SR 12813
- CAS No.
- 126411-39-0
- Chemical Name:
- SR 12813
- Synonyms
- GW485801;GW 485801;GW-485801;SR12813;SR 12813;SR-12813(GW 485801);SR-12813;SR12813;SR 12813;GW 485801;GW-485801;GW485801;GW-485801,GW485801,HMG-CoA Reductase (HMGCR),Autophagy,SR12813,inhibit,Inhibitor;Tetraethyl (2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl)bis(phosphonate);[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonicacidtetraethylester;Phosphonic acid, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P',P'-tetraethyl ester
- CBNumber:
- CB8497376
- Molecular Formula:
- C24H42O7P2
- Molecular Weight:
- 504.53
- MDL Number:
- MFCD00888473
- MOL File:
- 126411-39-0.mol
Last updated:2023-06-30 15:45:59
| Melting point | 119-121℃ |
|---|---|
| Boiling point | 552.6±50.0 °C(Predicted) |
| Density | 1.117±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: ≥10 mg/mL |
| form | solid |
| pka | 9.95±0.70(Predicted) |
| FDA UNII | 6Q7MN2PVB9 |
SR 12813 price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S4194 | SR 12813 ≥98%, solid | 126411-39-0 | 1mg | $56 | 2024-03-01 | Buy |
| Sigma-Aldrich | S4194 | SR 12813 ≥98%, solid | 126411-39-0 | 5mg | $187 | 2024-03-01 | Buy |
| Alfa Aesar | J67136 | SR 12813 98% | 126411-39-0 | 10mg | $159 | 2023-06-20 | Buy |
| Cayman Chemical | 18115 | SR 12813 ≥98% | 126411-39-0 | 10mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 18115 | SR 12813 ≥98% | 126411-39-0 | 50mg | $356 | 2024-03-01 | Buy |
SR 12813 Chemical Properties,Uses,Production
Uses
SR 12813 is a pregnane X receptor (PXR, NR 112) agonist.
Definition
ChEBI: An organic phosphonate that is the tetraethyl ester of [2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl]bis(phosphonic acid).
Biological Activity
Pregnane X receptor (PXR) agonist (EC 50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μ M concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.
Biochem/physiol Actions
SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.
storage
Store at +4°C
SR 12813 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 57)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4662 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
126411-39-0(SR 12813)Related Search:
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1of3
[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonicacidtetraethylester
SR-12813(GW 485801)
SR-12813;SR12813;SR 12813;GW 485801;GW-485801;GW485801
GW 485801
GW485801
GW-485801
SR12813;SR 12813
Phosphonic acid, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P',P'-tetraethyl ester
GW-485801,GW485801,HMG-CoA Reductase (HMGCR),Autophagy,SR12813,inhibit,Inhibitor
Tetraethyl (2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl)bis(phosphonate)
126411-39-0
C24H42O7P2