Varenicline tartrate
- CAS No.
- 375815-87-5
- Chemical Name:
- Varenicline tartrate
- Synonyms
- CS-291;Champix;Pidifix330;Pidifix-330;CP 526555-18;Unii-82269asb48;ChaMpix tartrate;Chantix tartrate;Varniclan tartrate;Varenicline tatrate
- CBNumber:
- CB91011765
- Molecular Formula:
- C17H19N3O6
- Molecular Weight:
- 361.35
- MDL Number:
- MFCD08460603
- MOL File:
- 375815-87-5.mol
- MSDS File:
- SDS
| Melting point | 206-208°C |
|---|---|
| storage temp. | room temp |
| solubility | DMSO: >5mg/mL |
| form | powder |
| color | white to beige |
| Stability | Hygroscopic |
| InChI | InChI=1/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/s3 |
| InChIKey | TWYFGYXQSYOKLK-UHFFFAOYSA-N |
| SMILES | [C@H](O)(C(=O)O)[C@@H](O)C(=O)O.C12=CC3=NC=CN=C3C=C1C1CNCC2C1 |&1:0,5,r| |
| NCI Dictionary of Cancer Terms | varenicline tartrate |
| FDA UNII | 82269ASB48 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P391-P501 | |||||||||
| Hazard Codes | Xn,N,T,F | |||||||||
| Risk Statements | 22-50-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 22-57-45-36/37-16-7 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Varenicline tartrate price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0004 | Varenicline tartrate ≥98% (HPLC) | 375815-87-5 | 5mg | $149 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0004 | Varenicline tartrate ≥98% (HPLC) | 375815-87-5 | 25mg | $591 | 2024-03-01 | Buy |
| Cayman Chemical | 15030 | Varenicline (tartrate) ≥98% | 375815-87-5 | 5mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 15030 | Varenicline (tartrate) ≥98% | 375815-87-5 | 10mg | $198 | 2024-03-01 | Buy |
| Cayman Chemical | 15030 | Varenicline (tartrate) ≥98% | 375815-87-5 | 25mg | $467 | 2024-03-01 | Buy |
Varenicline tartrate Chemical Properties,Uses,Production
Chemical Properties
Tan Solid
Uses
Varenicline tartrate is a prescription medication used to treat smoking addiction. Varenicline is a nicotinic receptor partial agonist. In this respect, it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement ther
Uses
Nicotinic α4β2 acetylcholine receptor partial agonist. Aid in smoking cessation.
Uses
Nicotinic a4? acetylcholine receptor partial agonist. Aid in smoking cessation.
Definition
ChEBI: A tartrate salt obtained by reaction of varenicline with one equivalent of (R,R)-tartaric acid. A partial agonist for nicotinic cholinergic receptors, it is used as an aid to giving up smoking.
brand name
Chantix (Pfizer).
Biological Activity
Orally active, subtype-selective partial agonist at α 4 β 2 nicotinic receptors (K i values are 0.06, 240, 322 and 3540 nM for α 4 β 2, α 3 β 4, α 7, α 1 β γ δ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo .
Biochem/physiol Actions
Varenicline tartrate is a partial α4β2 nicotinic receptor agonist and α7 full agonist. Varenicline competitively binds to α4β2 receptors and partially stimulates without creating a full nicotine effect, while simultaneoudly blocking the ability of nicotine to bind to the receptors. Varenicline thus blocks the ability of nicotine to activate α4β2 receptors and stimulate the central nervous mesolimbic dopamine system, believed to be the neuronal mechanism underlying reinforcement and reward experienced upon smoking.
storage
Room temperature
Varenicline tartrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 6000 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 | sales@czwytech.com | CHINA | 906 | 58 |
View Lastest Price from Varenicline tartrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-11-16 | Varenicline tartrate
375815-87-5
|
US $30.00-10.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-11-01 | Varenicline tartrate
375815-87-5
|
US $0.00-0.00 / kg | 0.1kg | 99.0%min | 200kg | Hangzhou ICH Biofarm Co., Ltd | |
 |
2023-09-06 | Varenicline tartrate
375815-87-5
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
-
- Varenicline tartrate
375815-87-5
- US $30.00-10.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Varenicline tartrate
375815-87-5
- US $0.00-0.00 / kg
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- Varenicline tartrate
375815-87-5
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
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