2,4,7-TRINITRO-9-FLUORENONE
- CAS No.
- 129-79-3
- Chemical Name:
- 2,4,7-TRINITRO-9-FLUORENONE
- Synonyms
- TNF;mTNF-α;tnf(ketone);TRINITROFLUORENONE;LABOTEST-BB LT00645370;2,4,7-trinitrofluorone;2,4,7-Trinirofluorenone;2,4,7-TRINITROFLUORENONE;2，4，7-Trinitrofluoren-9-one;2,4,7-trinitro-fluoren-9-on
- CBNumber:
- CB9210251
- Molecular Formula:
- C13H5N3O7
- Molecular Weight:
- 315.19
- MDL Number:
- MFCD00001142
- MOL File:
- 129-79-3.mol
| Melting point | 176-178°C |
|---|---|
| Boiling point | 454.77°C (rough estimate) |
| Density | 1.5148 (rough estimate) |
| refractive index | 1.5600 (estimate) |
| storage temp. | -20°C |
| form | powder |
| color | white |
| CAS DataBase Reference | 129-79-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | TNF |
| FDA UNII | B2290YT0WB |
| EPA Substance Registry System | 2,4,7-Trinitrofluoren-9-one (129-79-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 |
| Risk Statements | 23/24/25-33 |
| Safety Statements | 9-16-36/37/39 |
| RIDADR | 387 |
| WGK Germany | 3 |
| HazardClass | 1.1D |
| PackingGroup | II |
| Toxicity | LD50 oral in rat: 9910mg/kg |
2,4,7-TRINITRO-9-FLUORENONE Chemical Properties,Uses,Production
Uses
TNF-α influences the growth and function of both normal and neoplastic cells. TNF-α causes cytolysis or cytostasis of certain transformed cells being synergistic with γ-interferon in its cytotoxicity.
Uses
Tumor Necrosis Factor-α from mouse, a potent proinflammatory cytokine has been used:
- to activate MS1 endothelium cells
- to induce lipolysis in adipocytes
- to study its effect on liganded and unliganded glucocorticoid receptor (GR) in interleukin (IL)-6 and IL-8 gene regulation
General Description
Pale yellow needles (from acetic acid or benzene) or yellow powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Literature sources indicate that 2,4,7-TRINITRO-9-FLUORENONE is flammable. . Aromatic nitrates range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction.
Hazard
Suspected carcinogen. Mildly toxic by ingestion. A skin and eye irritant.
Fire Hazard
Literature sources indicate that 2,4,7-TRINITRO-9-FLUORENONE is flammable.
Biochem/physiol Actions
The TNFA (tumor necrosis factor α) gene is significantly associated with the regulation of innate and adaptive immune responses. Polymorphism of TNFA gene is known to cause acute motor axonal neuropathy. The cytokine release and gene action is associated with epithelial cells, myeloid cells, endothelial, as well as tumor cells. Tumor cells are known to release TNFA, specifically in response to chemotherapy
Safety Profile
Suspected carcinogen with experimental tumorigenic data. Mildly toxic by ingestion. Human mutation data reported. A skin and eye irritant. When heated to decomposition it emits hghly toxic fumes of NOx. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and KETONES.
Purification Methods
Crystallise it from nitric acid/water (3:1), wash it with water and dry it under vacuum over P2O5, or recrystallise it from dry *benzene. [Beilstein 7 II 410, 7 III 2348, 7 IV 1638.]
2,4,7-TRINITRO-9-FLUORENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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