JNJ 1661010
- CAS No.
- 681136-29-8
- Chemical Name:
- JNJ 1661010
- Synonyms
- 1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;CS-1527;Takeda-25;JNJ 1661010;JNJ 1661010, >=98%;JNJ 1661010 USP/EP/BP;TAKEDA-25;JNJ-1661010;JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;broad-spectrum,acid,inhibit,hydrolase,barrier,JNJ-1661010,FAAH,Takeda25,Fatty acid amide hydrolase,amide,Takeda 25,blood-brain,Inhibitor,analgesics,Fatty
- CBNumber:
- CB92457306
- Molecular Formula:
- C19H19N5OS
- Molecular Weight:
- 365.45
- MDL Number:
- MFCD00209157
- MOL File:
- 681136-29-8.mol
| Density | 1.340±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: ≥28mg/mL |
| form | solid |
| pka | 13.94±0.70(Predicted) |
| color | Off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| FDA UNII | 62521S57AU |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H315-H319-H335 |
| Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501 |
| WGK Germany | 1 |
JNJ 1661010 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14497 | JNJ-1661010 ≥98% | 681136-29-8 | 5mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 14497 | JNJ-1661010 ≥98% | 681136-29-8 | 10mg | $110 | 2024-03-01 | Buy |
| Cayman Chemical | 14497 | JNJ-1661010 ≥98% | 681136-29-8 | 25mg | $198 | 2024-03-01 | Buy |
| Cayman Chemical | 14497 | JNJ-1661010 ≥98% | 681136-29-8 | 50mg | $359 | 2024-03-01 | Buy |
| Tocris | 3262 | JNJ1661010 ≥99%(HPLC) | 681136-29-8 | 50 | $626 | 2021-12-16 | Buy |
JNJ 1661010 Chemical Properties,Uses,Production
Solubility
JNJ 1661010 is soluble to 100 mM in DMSO and to 10 mM in ethanol.
Description
JNJ-1661010 (681136-29-8) is a potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in vivo. JNJ-1661010 displays analgesic activity in various animal models.
Uses
JNJ-1661010, is used to examine the contribution of endocannabinoid signaling in experimental fibrosis. In biological studies, this compound had shown to elevate the levels of arachidonoyl ethanolamide (AEA) in rat brains.
Definition
ChEBI: JNJ-1661010 is a N-arylpiperazine.
Biological Activity
Selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC 50 = 12nM). Brain penetrant and active in vivo .
storage
Store at +4°C
References
1) Karbarz et al. (2009), Biochemical and biological properties of 4-(3-phenyl-[1,2,4]thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase; Anesth. Analg., 108 316
JNJ 1661010 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3082 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27894 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 18521735133 18521732826; | market@aladdin-e.com | China | 25014 | 65 |
View Lastest Price from JNJ 1661010 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | JNJ 1661010
681136-29-8
|
US $0.00-0.00 / KG | 5mg | 99% | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
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- JNJ 1661010
681136-29-8
- US $0.00-0.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd