6-ペンタデシルサリチル酸 化学特性,用途語,生産方法
外観
白色～うすい黄色、結晶～粉末
溶解性
メタノールに可溶
説明
Anacardic acid, isolated from cashew shells or several other medicinal plants, is the general name given to a family of four different 6-
alkyl salicyclic acids having varying degrees of unsaturation in the 15-
carbon alkyl chain. These compounds are associated with anti-
inflammatory, anti-
tumor, molluscicidal, and anti-
microbial activity. Literature frequently sites and gives the name anacardic acid to the completely-
saturated compound (6-
pentadecyl salicylic acid). Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-
activators p300 and p300/CREB-
binding protein-
associated factor (PCAF) with IC
50 values of 8.5 and 5 μM, respectively. At 25 μmol/L, anacardic acid suppresses NF-
κB activation, inhibits IκB-
α phosphorylation, and prohibits p65 nuclear translocation in KBM-
5 cells.
使用
Anacardic acid, isolated from cashew shells or several other medicinal plants, is the general name given to a family of four different 6-alkyl salicyclic acids having varying degrees of unsaturation in the 15-carbon alkyl chain. These compounds are associated with anti-inflammatory, anti-tumor, molluscicidal, and anti-microbial activity. Literature frequently sites and gives the name anacardic acid to the completely-saturated compound (6-pentadecyl salicylic acid). Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (PCAF) with IC50 values of 8.5 and 5 μM, respectively. At 25 μmol/L, anacardic acid suppresses NF-κB activation, inhibits IκB-α phosphorylation, and prohibits p65 nuclear translocation in KBM-5 cells.[Cayman Chemical]
一般的な説明
A cell-permeable ginkgolic acid (Cat. No. 345887) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC
50 = 2.2 μM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation. Both anacardic acid and ginkgolic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although anacardic acid is shown to inhibit p300 (Cat. No. 506200) and PCAF (Cat. No. 124026) histone acetyltransferase activities in cell-free acetylase assays (by 82% and 86%, respectively, at 10 μM). Also reported to inhibit the activity of prostaglandin synthase, tyrosinase, and lipoxygenase, as well as to enhance Aurora kinase A (Cat. No. 481413), but not Aurora kinase B, autophosphorylation and kinase activity by inducing conformation change and enhancing ATP binding.
6-ペンタデシルサリチル酸 上流と下流の製品情報
原材料
準備製品