オリバシン 化学特性,用途語,生産方法
解説
1,5-dimethyl-6H-pyrido[4.3-b]carbazole．C17H14N2(246.31)．オリバシン, キョウチクトウ科Aspidosperma olivaceum，A.longepetiolatum，A.australeなどに含まれるインドールアルカロイドの一つ．黄色の柱状晶．融点317～325 ℃(分解)．希アルコール溶液は蛍光を発する．λmax 224，238，276，287，292，314，329，375 nm(log ε 4.39，4.33，4.70，4.85，4.83，3.66，3.80，3.66．エタノール)．pKa 7.91±0.40．メタノール，アセトン，クロロホルムに可溶，水に難溶．森北出版「化学辞典（第2版）
説明
This alkaloid has recently been shown to exhibit a marked antineoplastic activity.
Administration of 25 or 50 mg/kg intraperitoneally on alternate days or daily until
death to mice which had been inoculated with a single intraperitoneal dose of
106 -102 LI2l0 leukemia cells increased the survival time by 89-229 per cent
compared with control animals.
Japanese workers have recently reported the synthesis of olivacine by heating
indole with 4(1-hydroxyethyl)-3-methoxymethyl-2-methylpyridine in 47 per
cent HBr.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 27, p. 1751, 1990
DOI: 10.1002/jhet.5570270645
参考文献
Regina et al., Cienc. Cult. (Sao Paulo), 26, 517 (1974)
Synthesis:
Kametani et al., J. Chern. Soc., Perkin I, 2102 (1975)
オリバシン 上流と下流の製品情報
原材料
準備製品