1-(2-ヒドロキシエトキシメチル)-6-フェニルチオチミン 化学特性,用途語,生産方法
解説
C8H20O7P2(290.22)．略号TEPP．ジエチルホスホロクロリダートを注意深く加水分解すると得られる．
"甘味を帯びたエステル臭をもつ粘性の高い液体．沸点124 ℃(133 Pa)．d204 1.185．n20D 1.4196．水に易溶，アセトン，メタノール，ベンゼン，クロロホルムなど種々の有機溶媒に可溶．エステラーゼ類に対する強力な阻害作用を示し，有機リン酸系殺虫研究の端緒となった化合物である．殺虫剤として残留性は少なく，速効性があるが，毒性が強いので，現在は使用されていない．LD50 0.5 mg/kg(ラット，経口)．[CAS 107-49-3]
森北出版「化学辞典（第2版）
用途
農薬(殺虫剤)
化学的特性
Water-white to amber liquid depending
on purity; hygroscopic. Miscible
with water and all organic solvents except aliphatic
hydrocarbons; hydrolyzed in water with formation
of mono-, di-, and triethyl orthophosphates; water
solutions attack metals; commercial material contains
40% TEPP.
物理的性質
Colorless to amber liquid with an agreeable, fruity odor
使用
Insecticide for aphids and mites, rodenticide.
一般的な説明
Water-white to amber liquid, depending on purity.
空気と水の反応
Hygroscopic. Hydrolyzed in water with formation of mono. di, and triethyl orthophosphates, water solutions attack metal surfaces. Reacts slowly with water to form phosphoric acid
反応プロフィール
Organophosphates, such as TETRAETHYL PYROPHOSPHATE, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
危険性
Toxic by skin contact, inhalation, or
ingestion; rapidly absorbed through skin; repeated
exposure may, without symptoms, be increasingly
hazardous; cholinesterase inhibitor, use may be
restricted.
健康ハザード
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
火災危険
Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
安全性プロファイル
Human poison by ingestion and intramuscular routes. Experimental poison by ingestion, skin contact, intraperitoneal, intramuscular, subcutaneous, parenteral, and intravenous routes. Human systemic effects by ingestion, intramuscular, and parenteral routes: paresthesia, wakefulness, excitement, muscle contraction or spasticity, nausea or vomiting and other gastrointestinal changes. The action is sidar to that of parathion: causing an irreversible inhbition of the cholinesterase molecules and the consequent accumulation of large amounts of acetylcholine. Small doses at frequent intervals are largely additive. When heated to decomposition it emits toxic fumes of POx. See also PARATHION.
職業ばく露
A potential danger to those engaged in the manufacture, formulation and application of this aphicide and acaricide; used as an insecticide to control aphids, thrips, and mites; as an anticholinesterase.
環境運命予測
Chemical/Physical. Tetraethyl pyrophosphate is quickly hydrolyzed by water. The
hydrolysis half-lives at 25 and 38°C are 6.8 and 3.3 hours, respectively (Sittig, 1985).
Decomposes at 170–213°C releasing large amounts of ethylene (Hartley and Kidd,
1987; Keith and Walters, 1992).
輸送方法
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. Note: See T:0305 for TEPP 1compressd gas.
不和合性
Tetraethyl pyrophosphate may be susceptible to formation of highly toxic and flammable phosphine gas in the presence of hydrides and other strong reducing agents. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Hygroscopic. Hydrolyzed in water with formation of mono. di-, and triethyl-orthophosphates. Reacts slowly with cold water forming phosphoric acid. Attacks metals in the presence of water.
廃棄物の処理
Return refillable compressed gas cylinders to supplier. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. TEPP is 50% hydrolyzed in water in 6.8 hours @ 25℃, and 3.3 hours @ 38℃; 99% hydrolysis requires 45.2 hours @ 25 ℃, or 21.9 hours @ 38℃. Hydrolysis of TEPP yields nontoxic products. Incineration is, however, an option for TEPP disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
1-(2-ヒドロキシエトキシメチル)-6-フェニルチオチミン 上流と下流の製品情報
原材料
1,2,4-Triazin-6(1H)-one, 2,5-dihydro-5-(1-methylethyl)-
1,2,4-Triazin-6(1H)-one, 2,5-dihydro-5-methyl-
Phosphoramidic acid, N-(phenylmethyl)-, diethyl ester
MONOTHIONO TEPP
ベンズアルデヒド
オルトぎ酸トリエチル
N-ベンジリデンベンゼンメタンアミン
りん酸O,O-ジエチル
亜りん酸ジエチル
クロロりん酸ジエチル
準備製品