リアノドール3-(1H-ピロール-2-カルボキシラート) 化学特性,用途語,生産方法
外観
白色～わずかにうすい褐色、結晶性粉末～粉末
溶解性
メタノールに可溶
説明
Ryania insecticide is the ground stem wood of the
tropical tree Ryania speciosa Vahl., and it contains over a
dozen of several structurally related alkaloids. Nowadays,
this botanical preparation is of minor importance, but
one of its major ingredients, ryanodine, is a widely used
pharmacological tool in studies of the calcium release
channels in sarcoplasmic reticulum membranes of skeletal
and cardiac muscle of both insects and mammals (11,12).
化学的特性
white to off-white solid
使用
Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum with potential application towards the treatment of huntingtons disease.
定義
ChEBI: An insecticide alkaloid isolated from South American plant Ryania speciosa.
生物活性
Potent inhibitor of Ca 2+ release from sarcoplasmic reticulum (IC 50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).
参考文献
Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)
Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968)
リアノドール3-(1H-ピロール-2-カルボキシラート) 上流と下流の製品情報
原材料
準備製品