KN-93

KN-93 価格 もっと(9)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01W0111-0064	KN-93	139298-40-1	1mg	￥25900	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01W0111-0064	KN-93	139298-40-1	5mg	￥81500	2024-03-01	購入
東京化成工業	K0055	KN-93 >98.0%(HPLC) KN-93 >98.0%(HPLC)	139298-40-1	5mg	￥13400	2024-03-01	購入
東京化成工業	K0055	KN-93 >98.0%(HPLC) KN-93 >98.0%(HPLC)	139298-40-1	25mg	￥46500	2024-03-01	購入
Sigma-Aldrich Japan	K1385	≥98% (HPLC) KN-93 ≥98% (HPLC)	139298-40-1	0.1mg	￥23900	2024-03-01	購入

KN-93 化学特性,用途語,生産方法

外観

白色～ほとんど白色, 結晶性粉末～粉末

溶解性

メタノールに溶ける。

用途

阻害剤。

説明

KN-93 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII), competitively blocking CaM binding to the kinase (K_i = 370 nM). It does not affect the activities of PKA, PKC, MLCK, or Ca²⁺-phosphodiesterase. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC₅₀ = 300 nM). More recently, KN-93 has been used to implicate roles for CaMKII in Ca²⁺-induced Ca²⁺ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca²⁺-dependent activation of HIF-1α in colon cancer cells.

化学的特性

white to off-white powder

使用

KN-93 has been used:

• as an inhibitor to block αCaMKII (Ca²⁺/calmodulin-dependent protein kinase IIα)
• as CaMKII inhibitor to pre-treat hippocampal slices
• to treat the cells, to alter the cytoskeleton (CSK) structure and function during the experiment

定義

ChEBI: A sulfonamide resulting from the formal condensation of p-methoxybenzenesulfonic acid with the anilino nitrogen of 2-(aminomethyl)-N-(2-hydroxyethyl)aniline in which the hydrogens of the primary amino group have been replace by methyl and p-chlorocinnamyl groups. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent protein kinase II.

一般的な説明

Cell-permeable, reversible, and competitive inhibitor of rat brain Ca⁺²/calmodulin-dependent protein kinase II (K_i = 370 nM). KN-93 selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effect on protein kinase A activity. Induces G₁ cell cycle arrest and apoptosis in NIH 3T3 cells.

生物活性

Potent inhibitor of CaM kinase II (IC 50 = 0.37 μ M). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC 50 = 307 nM for Kv1.5); independent of CaM kinase II inhibition.

KN-93 上流と下流の製品情報

原材料

準備製品

KN-93 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58

139298-40-1(KN-93)キーワード:

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• 139298-40-1
• 2-[N-(2-HYDROXYETHYL)-N-(4-METHOXYBENZENESULFONYL)]AMINO-N-(4-CHLOROCINNAMYL)-N-METHYLBENZYLAMINE
• METHOXYBENZENE-SULFONAMIDE
• KN-93
• KN-93, WATER-SOLUBLE
• N-[2-[[[3-(4'-CHLOROPHENYL)-2-PROPENYL]METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4'-METHOXY-BENZENESULFONAMIDE PHOSPHATE
• N-[2-[[[3-(4-CHLOROPHENYL)-2-PROPENYL]METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4-METHOXYBENZENESULPHONAMIDE
• N-[2-N-4-CHLOROCINNAMYL-N-METHYLAMINOMETHYLPHENYL]-N-[2-HYDROXYETHYL]-4-METHOXYBENZENESULFONAMIDE
• KN-93,98%
• KN-932-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
• N-[2-[N-(4-Chlorocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate salt
• N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
• n-[2-[[[3-(4'-chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-n-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide phosphate salt
• N-[2-[[[3-(4-Chlorophenyl)-2-propen-1-yl]MethylaMino]Methyl]phenyl]-N-(2-hydroxyethyl)-4-MethoxybenzenesulfonaMide
• N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4-METHOXYBENZENESULFONAMIDE
• KN-93;KN 93;KN93
• KN-93-H3PO4
• KN 93 N-[2-[[[3-(4-Chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
• N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxyb
• InSolution? KN-93
• KN-93(free base)
• KN-93 - CAS 139298-40-1 - Calbiochem
• InSolution KN-93 - CAS 139298-40-1 - Calbiochem
• CS-1099
• KN-93 base or HCI
• KN KN
• N-?[2-?({[(2E)?-?3-?(4-?CHLOROPHENYL)?PROP-?2-?EN-?1-?YL]?(METHYL)?AMINO}?METHYL)?PHENYL]?-?2-?HYDROXY-?S-?(4-?METHOXYPHENYL)?ETHANESULFONAMIDO
• Benzenesulfonamide, N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-
• N-[2-[[[3-(4-Chlorophenyl)allyl](methyl)amino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
• Inhibitor,Calmodulin-dependent protein kinases,Autophagy,KN-93,KN 93,KN93,Calmodulin-dependent kinases,inhibit,CaMK
• KN 93 (Z/E form)
• KN-93
• N-(2-ヒドロキシエチル)-N-[2-[[N-[(E)-3-(4-クロロフェニル)-2-プロペニル]-N-メチルアミノ]メチル]フェニル]-4-メトキシベンゼンスルホンアミド
• 2-[2-ヒドロキシエチル(4-メトキシフェニルスルホニル)アミノ]-N-(4-クロロシンナミル)-N-メチルベンゼンメタンアミン
• N-[2-({[(2E)-3-(4-クロロフェニル)プロパ-2-エン-1-イル](メチル)アミノ}メチル)フェニル]-N-(2-ヒドロキシエチル)-4-メトキシベンゼン-1-スルホンアミド