5-(4’-メチル-1,1’-ビフェニル-2-イル)-1-トリフェニルメチル-1H-テトラゾル
5-(4’-メチル-1,1’-ビフェニル-2-イル)-1-トリフェニルメチル-1H-テトラゾル 物理性質
- 融点 :
- 166-169 °C(Solv: ethyl acetate (141-78-6); dichloromethane (75-09-2))
- 沸点 :
- 681.6±65.0 °C(Predicted)
- 比重(密度) :
- 1.13±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- Inert atmosphere,Room Temperature
- 溶解性:
- クロロホルム（わずかに）
- 外見 :
- 個体
- 酸解離定数(Pka):
- 0.30±0.10(Predicted)
- 色:
- オフホワイト
- CAS データベース:
- 124750-53-4(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
5-(4’-メチル-1,1’-ビフェニル-2-イル)-1-トリフェニルメチル-1H-テトラゾル 価格
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5-(4’-メチル-1,1’-ビフェニル-2-イル)-1-トリフェニルメチル-1H-テトラゾル 化学特性,用途語,生産方法
化学的特性
Off-white Solid
使用
An intermediate in the preparation of labelled Candesartan.
合成
5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole is prepared by the reaction of trityl chloride and 2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl. The specific synthesis steps are as follows:
Dissolve compound 2 (200 g) with stirring at 40°C 700mL of acetone, Aqueous sodium hydroxide solution (40.67 g sodium hydroxide dissolved in 160 mL water) is added, Continue stirring for 1h, A solution of triphenylchloromethane in acetone (270.8 g of triphenylmethyl chloride dissolved in 800 mL of acetone) was initially added dropwise. The solid was added dropwise and gradually evolved into a white turbid liquid. The reaction was monitored by TLC until it was completely filtered off and washed with water to give a solid as intermediate 3. The solid was blow dried at 50°C to give white intermediate 3 (385 g), yield: 95.2%, HPLC: 99.44%.
5-(4’-メチル-1,1’-ビフェニル-2-イル)-1-トリフェニルメチル-1H-テトラゾル 上流と下流の製品情報
原材料
準備製品
5-(4’-メチル-1,1’-ビフェニル-2-イル)-1-トリフェニルメチル-1H-テトラゾル 生産企業
Global( 172)Suppliers
124750-53-4(5-(4’-メチル-1,1’-ビフェニル-2-イル)-1-トリフェニルメチル-1H-テトラゾル)キーワード:
- 124750-53-4
- 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole
- 5-[4'-METHYL (1,1'-BIPHENYL)-2-YL]-1-TRIPHENYLMETHYL-TETRAZOLE
- n-(triphenylmethyl)-5-(4'-methylbiphenyl-2-yl-)terazole
- N-(TRIPHENYLMETHYL)-5-(4'-METHYLBIPHENYL-2-YL)TETRAZOLE
- 5-(4'-Methyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole
- 5-[4''-METHYL (1,1''-BIPHENYL)-2-YL]-1-TRIPHENYLMETHYL-TETRAZOLE 98.5+%
- N-TriphenylMethyl-5-[4'-Methylbiphenyl-2-yl]tetrazole-d4
- 5-(4'-Methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
- ENTERPRISESTANDARD
- 5-(5-Methyl-2-phenylphenyl)-1-(triphenylMethyl)-1H-1,2,3,4-tetrazole
- Losartan IMpurity (5-(4'-Methylbiphenyl-2-yl)-1-Trityl-1H-Tetrazole)
- TTMB
- 5-[2-(4-methylphenyl)phenyl]-1-trityltetrazole
- N-(Triphenylmethyl)-5-(4'-Methylbiphenyl-2-Yl-)Tetrazole (Ttmb)
- Olmesartan TTMB impurity
- 1-[2-(diphenylmethyl)phenyl]-5-[2-(4-methylphenyl)phenyl]tetrazole
- Losartan Impurity 9
- Olmesartan Medoxomil impurity 8/Olmesartan TTMB Impurity/5-(4'-Methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
- 1H-Tetrazole, 5-(4'-methyl[1,1'-biphenyl]-2-yl)-1-(triphenylmethyl)-
- Losartan Impurity （5-?(4’-?Methyl-?[1,?1’-?biphenyl]?-?2-?yl)?-?1-?trityl-?1H-?tetrazole）
- 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole USP/EP/BP
- 5-?(4'-?Methyl-?[1,?1'-?biphenyl]?-?2-?yl)?-?1-?trityl-?1H-?tetrazole
DISCONTINUED. Please see T889170
- Olmesartan Medoxomil Impurity 24（Losartan Impurity 9）
- 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole
- 5-(4'-Methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
- 5-(4’-メチル-1,1’-ビフェニル-2-イル)-1-トリフェニルメチル-1H-テトラゾル