(3Α)-アロプレグナノロン 化学特性,用途語,生産方法
効能
抗うつ薬, 抗てんかん薬, GABA-A受容体モジュレータ
説明
Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone . It acts as a positive allosteric modulator of GABA
A receptors at nM concentrations (exhibiting the greatest potentiation at isoforms containing δ subunits) and of GABA
C receptors at μM concentrations. Allopregnanolone displays effects similar to other GABA
A receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.
使用
(3α)-Allopregnanolone acts as a GABAA receptor positive allosteric modulator. (3α)-Allopregnanolone is a metabolite of Progesterone (P755900). (3α)-Allopregnanolone is a neuroactive steroid present in the blood and also the brain.
生物活性
GABA A receptor positive allosteric modulator. Neuroactive steroid.
(3Α)-アロプレグナノロン 上流と下流の製品情報
原材料
準備製品