N-(tert-ブトキシカルボニル)-L-グルタミン酸ジメチル
N-(tert-ブトキシカルボニル)-L-グルタミン酸ジメチル 物理性質
- 融点 :
- 43.0 to 47.0 °C
- 沸点 :
- 370.9±32.0 °C(Predicted)
- 比重(密度) :
- 1.117±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Keep in dark place,Sealed in dry,Room Temperature
- 溶解性:
- クロロホルム（微量）、DMSO（微量）
- 酸解離定数(Pka):
- 10.86±0.46(Predicted)
- 外見 :
- 液体
- 色:
- 無色～淡黄色
- InChI:
- InChI=1S/C12H21NO6/c1-12(2,3)19-11(16)13-8(10(15)18-5)6-7-9(14)17-4/h8H,6-7H2,1-5H3,(H,13,16)/t8-/m0/s1
- InChIKey:
- QNSPKWUAZQIIGZ-QMMMGPOBSA-N
- SMILES:
- C(OC)(=O)[C@H](CCC(OC)=O)NC(OC(C)(C)C)=O
- CAS データベース:
- 59279-60-6(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
吸入すると有害 |
急性毒性、吸入 |
4 |
警告 |
|
P261, P271, P304+P340, P312 |
| H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
N-(tert-ブトキシカルボニル)-L-グルタミン酸ジメチル 価格
もっと(16)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01APOOR313088 |
N-Boc-L-グルタミン酸ジメチルエステル
N-BOC-L-Glutamic acid dimethyl ester |
59279-60-6 |
50g |
￥88800 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01APOOR313088 |
N-Boc-L-グルタミン酸ジメチルエステル
N-BOC-L-Glutamic acid dimethyl ester |
59279-60-6 |
250g |
￥264000 |
2023-06-01 |
購入 |
|
東京化成工業
|
D4536 |
N-(tert-ブトキシカルボニル)-L-グルタミン酸ジメチル >98.0%(HPLC)(N)
Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate
>98.0%(HPLC)(N) |
59279-60-6 |
1g |
￥2000 |
2024-03-01 |
購入 |
|
東京化成工業
|
D4536 |
N-(tert-ブトキシカルボニル)-L-グルタミン酸ジメチル >98.0%(HPLC)(N)
Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate
>98.0%(HPLC)(N) |
59279-60-6 |
5g |
￥6300 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBST-7320 |
Boc-Glu(OMe)-OMe |
59279-60-6 |
5g |
￥10000 |
2024-03-01 |
購入 |
N-(tert-ブトキシカルボニル)-L-グルタミン酸ジメチル 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
使用
(R)-N-Boc-glutamic acid-1,5-dimethyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical production processes.
合成
L-glutamic acid (10.0 g, 67.97 mmol) was dissolved in 200 mL of methanol, and SOCl2(10.85 mL, 149.53 mmol)was slowly added dropwise under an ice bath. After the addition, reflux was performed at 65 ?? C. After 2 hours, the reaction system was cooled to room temperature, and methanol was evaporated to dryness under reduced pressure to obtain a colorless viscous substance.This colorless viscous substance was dissolved in 200 mL of THF, (Boc)2O (22.25 g, 101.95 mmol) was addedunder an ice bath, and triethylamine (14.13 mL, 101.95 mmol) was slowly added dropwise.After the addition was complete, the reaction was allowed to proceed at room temperature overnight.After completion of the reaction, the solvent was distilled off under reduced pressure.The residue was dissolved in 200 mL of dichloromethane.The organic phase was washed with water (200 mL * 2), saturated citric acid solution (200 mL * 2), saturated sodium bicarbonate solution (200 mL * 2), and saturated brine (200 mL * 2) in that order.The organic phase was dried over anhydrous Na2SO4. Thefiltrate was collected by filtration, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 4: 1 v / v) to give a colorless oily product (R)-N-Boc-glutamic acid-1,5-dimethyl ester (18.34 g, yield 98%)
N-(tert-ブトキシカルボニル)-L-グルタミン酸ジメチル 上流と下流の製品情報
原材料
準備製品
N-(tert-ブトキシカルボニル)-L-グルタミン酸ジメチル 生産企業
Global( 318)Suppliers
59279-60-6(N-(tert-ブトキシカルボニル)-L-グルタミン酸ジメチル)キーワード:
- 59279-60-6
- Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate
- N-ALPHA-TERT-BUTYLOXYCARBONYL-L-GLUTAMIC ACID DI-METHYL DIESTER
- N-ALPHA-T-BUTYLOXYCARBONYL-L-GLUTAMIC ACID DIMETHYL DIESTER
- N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMIC ACID ALPHA, GAMMA-DIMETHYL ESTER
- (R)-N-BOC-GLUTAMIC ACID-1,5-DIMETHYL ESTER
- (S)-2-tert-ButoxycarbonylaMinopentanedioic acid diMethyl ester
- N-alpha-t-Butyloxycarbonyl-L-glutamic acid di-methyl ester
- Dimethyl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate
- N-Boc-L-GlutaMic Acid diMethyl ester/(S)-2-tert-ButoxycarbonylaMino-pentanedioic acid diMethyl ester
(S)-2-tert-ButoxycarbonylaMino-pentanedioic acid diMethyl ester
- N-Boc-L-glutaMic acid 1,5-diMethyl ester, 97%
- N-α-(t-Butoxycarbonyl)-L-glutamic acid α,γ-dimethyl ester
- (R)-N-Boc-glutamic acid-1,5-dimethyl ester （PF-07321332 Paxlovid intermediate）
- Dimethyl Boc-Glutamate
- 59279-60-6---(R)-N-Boc-glutamic acid-1,5-dimethyl ester
- 1,5-dimethyl (2S)-2-{[(tert-butoxy)carbonyl]amino}pentanedioate
- (R)-N-Boc-glutamic acid-1，5-dinethyl ester
- (Tert-Butoxy)Carbonyl Glu(OMe)-OMe (Syrup)
- Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate >
- u(Ome)-OMe
- L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1,5-dimethyl ester
- imethyl(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate
- N-(tert-Butoxycarbonyl)-L-glutamic Acid Dimethyl Ester
- Dimethyl N-Boc-L-glutamate
- (R)-N-Boc-glutamic acid-1,5-dimethyl ester USP/EP/BP
- Boc-Glu-OMe(OMe) USP/EP/BP
- BOC-L-GLU(OME)-OME
- BOC-L-GLUTAMIC ACID DIMETHYL ESTER
- BOC-GLU(OME)-OME
- BOC-GLU(OME)-OME 45G
- N-Boc-L-Glutamic acid dimethyl ester
- N-(tert-ブトキシカルボニル)-L-グルタミン酸ジメチル
- N-Boc-L-グルタミン酸ジメチル
- N-BOC-L-グルタミン酸ジメチルエステル