エコチオパートヨウ化物
エコチオパートヨウ化物 価格
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エコチオパートヨウ化物 化学特性,用途語,生産方法
効能
縮瞳薬, アセチルコリンエステラーゼ阻害薬
使用
Cholinergic (ophthalmic).
使用
Echothiophate is a phosphorylthiocholine with pharmacological action analogous to that
of isofluorophate; however, spontaneous reduction of phosphorylated enzyme occurs
faster after using isofluorophate. It is used in various forms of glaucoma.
定義
ChEBI: The iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.
臨床応用
Echothiophate iodide has found therapeutic application for the treatment of glaucoma and strabismus. Echothiophate is applied topically as a
solution and is the only irreversible AChEI for the treatment of glaucoma. The decrease in intraocular pressure observed can last up to 4 weeks.
Phosphoester AChEIs exhibit cataractogenic properties; thus, their use should be reserved for patients who are refractory to other forms of
treatment (i.e., short-acting miotics, β-blockers, epinephrine, and possibly, carbonic anhydrase inhibitors). Because of its toxicity, echothiophate
is not used for its systemic action. Selectivity of echothiophate for the AChE catalytic site was enhanced by incorporation in the molecule of a
quaternary ammonium salt functional group two carbons removed from the phosphoryl group.
合成
Echothiophate, S-(2-trimethylaminoethyl)-O,O-diethylthiophosphate
(13.2.23), is made by reacting diethylchlorophosphoric acid with 2-dimethylaminoethylmercaptane, giving S-(2-dimethylaminoethyl)-O,O-diethylthiophosphate (13.2.22), which is
alkylated by methyliodide, forming echothiophate (13.2.23) [51].
エコチオパートヨウ化物 上流と下流の製品情報
原材料
準備製品
エコチオパートヨウ化物 生産企業
Global( 15)Suppliers
513-10-0(エコチオパートヨウ化物)キーワード:
- 513-10-0
- ECOTHIOPATE IODIDE
- 217MI
- Ecothiopate
- Ecostigmine
- ECOTHIOPHATE
- ECHOTHIOPHATE
- PHOSPHOLINEIODIDE
- 2-[(Diethoxyphosphinyl)thio]ethanaminium
- 2-(diethoxyphosphorylthio)ethyl-trimethyl-ammonium iodide
- 2-diethoxyphosphorylsulfanylethyl(trimethyl)azanium iodide
- 2-(diethoxyphosphinylthio)ethyltrimethylammonium iodide
- Diethoxyphosphinylthiocholine iodide
- Diethylphosphorylthiocholine iodide
- Echothiopate iodide
- EcostigMini jodiduM
- Ecothiophate iodide
- Echodide
- Ecostigmini Sodidum
- Iodide, Echothiophate
- エコチオパート
- 2-[(ジエトキシホスフィニル)チオ]エタンアミニウム
- ヨウ化エコチオパート
- エコチオパートヨウ化物
- エコチオパートヨウ化物 (JP17)
- エコチオファートイオジド
- ヨウ化エコチオファート
- エコチオファートヨージド
- 2-[(ジエトキシホスフィニル)チオ]-N,N,N-トリメチルエタンアミニウム・ヨージド