オートカムチド2関連抑制性ペプチド 化学特性,用途語,生産方法
使用
Autocamtide 2-related inhibitory peptide has been used:
- To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophages
- To study its influence on oxidative stress associated with neural cell death after hypoxia-ischemia, using neonatal hippocampal slice cultures
- To quench the phosphorylation of recombinant synGA (GTPase-activating protein) induced by CaMKII
Biochem/physiol Actions
Calmodulin kinase II facilitates the calcium-dependent L-type calcium channels. Autocamtide 2-related inhibitory peptide action does not influence cAMP (cyclic adenosine monophosphate)-dependent protein kinase II, calmodulin-dependent protein kinase IV and protein kinase C. Increased expression of calmodulin kinase II is observed in structural heart disease, indicated by myocardial infarction. Thus, inhibition of calmodulin kinase II activity might serve as a protective effect against structural heart disease, as it is found to prevent cardiac hypertrophy, dilation and dysfunction.
オートカムチド2関連抑制性ペプチド 上流と下流の製品情報
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