포르볼
|
|
포르볼 속성
- 녹는점
- 162-163° and 233-234°; mp 249-250°
- 알파
- D24 +102° (water); D20 +118° (c = 0.4 in dioxane)
- 끓는 점
- 415.62°C (rough estimate)
- 밀도
- 1.4
- 굴절률
- 1.4450 (estimate)
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 수용성
- 물에 용해됨
- 용해도
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: slightly soluble; PBS (pH 7.2): 1 mg/ml
- 물리적 상태
- powder to crystal
- 산도 계수 (pKa)
- 11.36±0.70(Predicted)
- 색상
- White to Orange to Green
- InChIKey
- QGVLYPPODPLXMB-UBTYZVCOSA-N
- SMILES
- C1(=O)[C@]2(O)[C@]([H])([C@@]3(O)[C@H](C)[C@@H](O)[C@@]4(O)C(C)(C)[C@@]4([H])[C@]3([H])C=C(CO)C2)C=C1C
- CAS 데이터베이스
- 17673-25-5
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T+ | ||
---|---|---|---|
위험 카페고리 넘버 | 26/27/28-36/37/38 | ||
안전지침서 | 26-27-36/37/39-45-28 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | GZ0600000 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29062990 | ||
유해 물질 데이터 | 17673-25-5(Hazardous Substances Data) |
포르볼 C화학적 특성, 용도, 생산
개요
Phorbol is a diterpene originally isolated from croton oil. It is used as a starting material for the semisynthesis of various phorbol diesters, which are structurally analogous to diacylglycerol and activate PKC isoforms by associating with their C1 domains.용도
Phorbol is a plant-derived diterpene that exhibits various biological activities such as its role as tumor promoters through the activation of protein kinase C.제조 방법
Phorbol can be extracted from croton oil by two-phase alcoholysis and purified by high-speed counter-current chromatography[1]. The specific method is as follows:The optimized operation conditions of biphasic alcoholysis were a reaction time of 91 min, a temperature of 14°C, and a croton oil-methanol ratio of 1:30 (g:ml). The phorbol during the biphasic alcoholysis was 3.2-fold higher in content than that obtained in conventional monophasic alcoholysis. The optimized high-speed countercurrent chromatography method was using the ethyl acetate/n-butyl alcohol/water at 4.7:0.3:5 (v:v:v) with Na2SO4 at 0.36 g/10 ml as the solvent system, using the mobile phase flow rate of 2 ml/min, the revolution of 800 r/min, under which the retention of the stationary phase was achieved at 72.83%. The crystallized phorbol following high-speed countercurrent chromatography was obtained as high purity of 94%.
정의
ChEBI: A diterpenoid with the structure of tigliane hydroxylated at C-4, -9, -12(beta), -13 and -20, with an oxo group at C-3 and unsaturation at the 1- and 6-positions.일반 설명
White solid.공기와 물의 반응
Water soluble.반응 프로필
PHORBOL is unstable to prolonged exposure to air, light and ambient temperatures. PHORBOL is also sensitive to acid and alkalis and is subject to autooxidation. PHORBOL dissolves slowly, therefore solution in a desired solvent is best accomplished by prolonged shaking under an inert atmosphere. .화재위험
PHORBOL is probably combustible.포르볼 준비 용품 및 원자재
원자재
준비 용품
포르볼 공급 업체
글로벌( 101)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
Hpets Biotech Company (Chongqing) Co.,ltd | +8613340353813 |
info@hanpets.com | China | 26 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
sales@coreychem.com | China | 29914 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 |
sale02@cqherb.com | CHINA | 376 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 |
marketing1@neostarunited.com | China | 13172 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
포르볼 관련 검색:
PHORBOL
PHORBOL (12-MYRISTOYL-13-ACETYL),PHORBOL 12-MYRISTATE 13-ACETATE,phorbol12-tetradecanoate13-acetat
phorbol10,11-diacetat
PHORBOL-12-BUTYRATE
PHORBOL 12,13-DIBUTYRATE
PHORBOL 12,13-DIDECANOATE
PHORBOL 12-MYRISTATE-13-ACETATE-4-O-METHYL ETHER,PHORBOL 12-MYRISTATE 13-ACETATE 4-O-METHYL ETHER, 4BETA
PHORBOL 12-N-METHYLANTHRANILATE
PHORBOL 12-DECANOATE, 4BETA
PHORBOL 12,13,20-TRIACETATE, 4BETA
PHORBOL-12-MONOMYRISTATE,phorbol-12-myristat
PHORBOL 13-ACETATE,PHORBOL 13-MONOACETATE
PHORBOL 13-MYRISTATE
4-ALPHA-12-TETRADECANOYL PHORBOL 13-ACETATE
12-deoxy-phorbol,20-acetate-13-isobutyrat
PHORBOL 12-PHENYLACETATE 13-ACETATE 20-HOMOVANILLATE
PHORBOL 12,13-DINONANOATE 20-HOMOVANILLATE
4-Α-PHORBOL-12,13-DIDECANOATE