Milbemycin oxime
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Milbemycin oxime 속성
- 녹는점
- 169.6-177.4°
- 인화점
- 412℃
- 저장 조건
- Store at -20°C
- 용해도
- DMSO:100.0(Max Conc. mg/mL);91.13(Max Conc. mM)
- 물리적 상태
- 결정성 고체
- 안정성
- 흡습성
- InChIKey
- LKMMLHTWKLEARD-MGZQXKBQSA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
유엔번호(UN No.) | 2588 | ||
---|---|---|---|
WGK 독일 | 3 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 2932206000 | ||
독성 | LD50 orally in mice: 1000-1500 mg/kg (Ciba-Geigy) |
Milbemycin oxime C화학적 특성, 용도, 생산
용도
Milbemycin oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of two natural products, milbemycin A3 and A4 (in ~30:70 ratio). Milbemycin oxime is used therapeutically for the prevention of intestinal parasites in dogs. Like the other milbemycin/avermectins, it was developed for intestinal parasite control in animals and acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.Clinical Use
Milbemycin oxime (Milbemycin) is available as an oral chewable tablet (2.3–27 mg) for heartworm prevention in dogs and cats, as well as a 0.1% otic solution for treating ear mites. It is not available in a more concentrated dosage form, so overdoses are relatively rare[1].Veterinary Drugs and Treatments
Milbemycin tablets are labeled as a once-a-month heartworm preventative (Dirofilaria immitis) and for hookworm control (Ancylostoma caninum). It has activity against a variety of other parasites, including adult hookworms (A. caninum), adult roundworms (T. canis, T. leonina) and whipworms (Trichuris vulpis). In cats, milbemycin has been used successfully to prevent larval infection of Dirofilaria immitis.Milbemycin, like ivermectin can be used for treatment of generalized demodicosis in dogs, but treatment can be significantly more expensive. It is likely safer to use in breeds susceptible to mdr1 genetic mutation (Collies, Shelties, Australian shepherds, etc.) at the doses used for this indication, but neuro toxicity is possible. Older dogs, those that have had a long duration of disease prior to treatment, and dogs with pododemodicosis appear have a lower success rate with milbemycin treatment.
Milbemycin oxime 준비 용품 및 원자재
원자재
준비 용품
Milbemycin oxime 공급 업체
글로벌( 278)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Masteam Bio-tech Co., Ltd. | +86-15200345168 +86-15200345168 |
bruce.lei@masteam.com | CHINA | 153 | 58 |
Liaoning Pharmaceutical Innovation Co., Ltd | +8616588669988 |
sales@pipharma.com.cn | China | 150 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales05@airuikechemical.com | China | 994 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15956 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21689 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9341 | 55 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
Milbemycin oxime 관련 검색:
Milrinone Impurity 14
Milrinone Impurity 17
5-Decyano 5-(Ethyl Formate) Milrinone
Miconazole IMpurity I
Miconazole IMpurity B
MILRINONE RELATED COMPOUND A (50 MG) (1,6-DIHYDRO-2-METHYL-6-OXO(3,4'-BIPYRIDINE)-5-CAR-BOXAMIDE)
2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxylic acid
1,6-Dihydro-2-(hydroxyMethyl)-6-oxo-[3,4'-bipyridine]-5-carbonitrile
Isoconazole
Milbemycin EP Impurity D
Milrinone Impurity 13
Miconazole Impurity
Praziquantel
SPINETORAM
MilbeMycin A4 OxiMe
MilbeMycin A3 OxiMe
Ribonucleic acid
Milbemycin EP Impurity E