Cardioselective 1-adrenergic blocker. An antihypertensive; antiglaucoma
정의
ChEBI: A propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective
beta1-receptor blocker and is used in the treatment of glaucoma as well as hypertension, arrhythmias, and coronary heart disease. It is also used to reduce non-fatal cardiac events in patients with heart failure.
신진 대사
Absorption of an oral dose of betaxolol (Kerlone,
Betoptic) is almost complete. The drug is subject to a
slight first-pass effect such that the absolute bioavailability
of the drug is about 90%.Approximately 50% of
administered betaxolol binds to plasma proteins, and its
plasma half-life is about 20 hours; it is suitable for dosing
once per day.The primary route of elimination is by
liver metabolism, with only 15% of unchanged drug being
excreted.
