메틸 글리옥살

메틸 글리옥살 속성

메틸 글리옥살 MSDS

Pyruvaldehyde

메틸 글리옥살 C화학적 특성, 용도, 생산

개요

Methylglyoxal (MG) is a highly reactive a-dicarbonyl compound that is primarily generated endogenously during glycolytic pathways (glucose and fructose metabolism) in cells and exogenously due to autoxidation of sugar, degradation of lipids, and fermentation during food and drink processing. Methylglyoxal polymerizes readily; it is hygroscopic and incompatible with strong oxidizing agents and bases. Methylglyoxal may be present as a free molecule in the diet or bound to biological materials, such as proteins, and as advanced glycation end products (AGEs), which are poorly absorbed. Methylglyoxal has been indicated in pathological events associated with hyperglycemia in both type 1 and type 2 diabetes and in other diabetic complications as either a direct toxin or as a precursor for AGEs. In animal studies, MG has been shown to induce tumorigenesis, but has also been reported as a tumoristatic agent. Methylglyoxal has been identified as the dominant antibacterial constituent of manuka honey.

화학적 성질

clear yellow to yellow-brown solution

출처

Reported found in the dry distillate of Manilla copal. Also reported found in apple juice, orange juice, celery root, rutabaga, tomato, wheaten bread, white bread, roasted and raw turkey, cognac, roasted barley, beer, cocoa, coffee and roasted pecans.

용도

Methylglyoxal solution has been used:

• to assess glyoxalase 1 (GLO1) enzymatic activity
• as an advanced glycation end (AGE) forming agent for the preparation of albumin in vitro
• to regulate anxiety like behavior in mice
• to induce peritoneal fibrosis in rats
• to study the chromatographic retention characteristics of organic chemicals and metal DNA adducts
• for intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway

제조 방법

By distilling a dilute solution of dihydroxyacetone from calcium carbonate; by oxidation of acetone with selenium dioxide; by heating dihydroxy acetone with phosphorus pentoxide; by warming isonitroso acetone with diluted H2SO4.

정의

ChEBI: A 2-oxo aldehyde derived from propanal.

일반 설명

Clear yellow slightly viscous liquid with a pungent odor. Yellowish-green vapors. Faintly acidic to litmus.

공기와 물의 반응

Water soluble.

반응 프로필

Methylglyoxal polymerizes readily. Methylglyoxal is hygroscopic. Methylglyoxal is incompatible with strong oxidizing agents and bases. Methylglyoxal is an aldehyde. Aldehydes are frequently involved in self-condensation or polymerization reactions. These reactions are exothermic; they are often catalyzed by acid. Aldehydes are readily oxidized to give carboxylic acids. Flammable and/or toxic gases are generated by the combination of aldehydes with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. Aldehydes can react with air to give first peroxo acids, and ultimately carboxylic acids. These autoxidation reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction). The addition of stabilizers (antioxidants) to shipments of aldehydes retards autoxidation.

화재위험

Literature sources indicate that Methylglyoxal is nonflammable.

환경귀착

Methylglyoxal production and use as a chemical intermediate and flavoring agent may result in its release to the environment through various waste streams. If released into water, MG is not expected to adsorb to suspended solids and sediment based on the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon the estimated Henry’s Law constant. If released to soil, MG is expected to have very high mobility based upon an estimated Koc of 1 determined from the structure estimation method. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions.
Methylglyoxal serves as a substrate for the isozymes E1, E2, and E3 of human aldehyde dehydrogenase. Oxidation of MG by these isozymes generated pyruvate. Methylglyoxal is a partially oxidized compound obtained from the tropospheric oxidation of numerous hydrocarbons, of both biogenic and anthropogenic origin. If released to the air, an estimated vapor pressure of 27 mm Hg at 25 ℃ indicates MG will exist solely as a vapor in the atmosphere. Vapor-phase MG will be degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 30 h. Methylglyoxal absorbs light at wavelengths >290 nm and, therefore, is susceptible to direct photolysis by sunlight; half-lives of 2–4 h have been reported.

Purification Methods

Commercial 30% (w/v) aqueous solution is diluted to about 10% and distilled twice, taking the fraction boiling below 50o/20mm Hg. (This treatment does not remove lactic acid). [Beilstein 1 IV 3631.]

메틸 글리옥살 준비 용품 및 원자재

원자재

준비 용품

메틸 글리옥살 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18224	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58

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