Raltitrexed
|
|
Raltitrexed 속성
- 녹는점
- 176-1800C
- 밀도
- 1.49±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- H2O: ≥10mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 3.50±0.10(Predicted)
- 색상
- 황백색에서 밝은 노란색까지
- InChIKey
- IVTVGDXNLFLDRM-HNNXBMFYSA-N
- CAS 데이터베이스
- 112887-68-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/38-25-61 | ||
| 안전지침서 | 26-37/39-45-53 | ||
| 유엔번호(UN No.) | UN 2811 6.1 / PGIII | ||
| WGK 독일 | 2 | ||
| HS 번호 | 2934.99.4700 |
Raltitrexed C화학적 특성, 용도, 생산
개요
Tomudex was launched in Ireland, France, Luxembourg and the UK for advanced colorectal cancer and it was prepared in a convergent manner (6 steps) from diethyl L-glutamate and 6-bromomethyi-2-methyl-quinazolin4(3H)-one. Tomudex is a highly selective inhibitor of thymidylate synthase (TS), the key enzyme in the biochemical conversion of dUMP to dTMP. It enters the cell via the reduced folatefmethotrexate cell membrane carrier and is converted to the polyglutamate species by folylpolyglutamate synthase within 4h where it then binds to the folate substrate site of TS. Clinically, it had a 29% response rate in patients with advanced colorectal cancer. It is water soluble, can be administered as a single dose every three weeks and had no hepto- or nephrotoxicity.화학적 성질
Yellow Crystalline Powder용도
Folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. AntineoplasticRaltitrexed 준비 용품 및 원자재
원자재
준비 용품
Raltitrexed 공급 업체
글로벌( 356)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49739 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 |
salesvip2@hntmhg.com | China | 415 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. | 0431-80514535 13634302652 |
Extension@chemextension.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Casorganics US Corp | +17326109938 |
sales@casorganics.com | CHINA | 174 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Raltitrexed 관련 검색:
5-플루오로우라실 메토트렉세이트
Y27632 (hydrochloride)
Bosutinib
Pemetrexed Disodium
BI 2536
Milrinone
Quinazoline
2-AMINO-5-METHYLBENZAMIDE
Raltitrexed
5-(DIMETHYLAMINO)THIOPHENE-2-CARBALDEHYDE
4-HYDROXY-6-METHYLQUINAZOLINE
1400W
3-DIMETHYLAMINOMETHYL-BENZYLAMINE
2-[(2-thienylmethyl)amino]-1-butanol
(THIOPHENE-2-CARBONYL)-AMINO]-ACETIC ACID
6-(bromomethyl)-3,4-dihydro-2-methyl-4-oxoquinazoline (intermediate of raltitrexed)
5-nitro-2-thiophenic acid (intermediate of raltitrexed)