2-티오펜카복실산
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2-티오펜카복실산 속성
- 녹는점
- 125-127 °C(lit.)
- 끓는 점
- 260 °C(lit.)
- 밀도
- 1.42
- 굴절률
- 1.5160 (estimate)
- 인화점
- 259-261°C
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 아세톤(약간 용해됨), 클로로포름(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 3.49(at 25℃)
- 색상
- 흰색에서 황백색까지
- 수용성
- 80g/L(20℃)
- Merck
- 14,9354
- BRN
- 110150
- InChIKey
- QERYCTSHXKAMIS-UHFFFAOYSA-N
- LogP
- 1.570
- CAS 데이터베이스
- 527-72-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36-37/39 | ||
WGK 독일 | 3 | ||
RTECS 번호 | XM8330200 | ||
위험 참고 사항 | Irritant | ||
TSCA | Yes | ||
HS 번호 | 29349990 |
2-티오펜카복실산 C화학적 특성, 용도, 생산
화학적 성질
The substance is a light yellow crystal powder. It dissolves in hot water, ethanol, and ether, and is only slightly soluble in chloroform.용도
2-Thenoic Acid, is a sulfur-containing heterocyclic compound, used in the synthesis of pharmaceutical and biologically active compounds. It is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.생산 방법
Thiophene 2-Carboxylic Acid, T2CA, is prepared via oxidation of 2-acetylthiophene using hypochlorite, because oxidation of alkylthiophenes leads to general breakdown of the thiophene ring.정의
ChEBI: Thiophene-2-carboxylic acid is a thiophenecarboxylic acid in which the carboxy group is located at position 2. It is a conjugate acid of a thiophene-2-carboxylate.주요 응용
The sodium salt of 2-Thiophenecarboxylic acid(T2CA) is used to treat influenza (trophires). Other salts, e.g., the Li salt, have minor medicinal uses and the free acid is a mucolytic. A US Patent describes the use of the Na salt as a lubricating oil thickener. ?Suprofen, a nonsteroidal anti-inflammatory (NSAI), and tienilic acid (ticrynafen), a potent diuretic, were both very large prospective markets for T2CA or its acid chloride, but were almost completely withdrawn in the 1980s. Sanofi Aventis'NSAI tiaprofenic acid was comparatively successful in this market, but although it is still marketed it has subsequently been superceded by alternative products. The 5-nitro derivative of T2CA is used to produce nifurzide, an intestinal antibacterial. Pfizer's anti-inflammatory tenidap is a developing drug which uses the acid chloride of T2CA as the starting intermediate.Purification Methods
Crystallise the acid from water and dry it in a vacuum. The amide has m 181o(from H2O) and pK2 5 10.54(50% aqueous dioxane). [Beilstein 18 H 289, 18 I 438, 18 II 269, 18 III/IV 4011, 18/6 V 158.]2-티오펜카복실산 준비 용품 및 원자재
원자재
준비 용품
BIS(2-THIENYL) KETONE
5-Nitrothiophene-2-carboxylic acid
2-THIOPHENECARBOXYLIC ACID SODIUM SALT
7-DIETHYLAMINO-3-THENOYLCOUMARIN
5-브로모티오펜-2-카르보니트릴
5-tert-부틸-티오펜-2-카르복실산
5-Bromo-2-thiophenecarboxylic acid
2-THIOPHENAMINE
3-BROMOTHIOPHENE-2-CARBOXAMIDE
2-(Chloromethyl)thiophene
3-(티오펜-2-일)이속사졸-5-아민
CIS-3-펜텐-1-OL
메틸4,5-디클로로티오펜-2-카르복실레이트
2-Thienylmethanethiol
5-아미노-티오펜-2-카르복실산메틸에스테르
TRANS-2-PENTEN-1-OL
2-티오펜카복실산 공급 업체
글로벌( 568)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 6011 | 58 |
Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 |
sales@kindchem.cn | China | 1227 | 58 |
Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 |
da@zhongda-biotech.com | China | 248 | 58 |
Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 |
justine@zhongda-biotech.com | China | 300 | 58 |
Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 |
linda@zhongda-biotech.com | China | 204 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 18219 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales01@airuikechemical.com | China | 994 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15956 | 58 |