하이드로퀴논모노벤질에터

하이드로퀴논모노벤질에터 속성

하이드로퀴논모노벤질에터 MSDS

PBP

하이드로퀴논모노벤질에터 C화학적 특성, 용도, 생산

개요

4-(Benzyloxy)phenol, also called monobenzone and monobenzyl ether of hydroquinone (MBEH) is an organic chemical in the phenol family with chemical formula C6H5CH2OC6H4OH. It is used as a topical drug for medical depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water.
The topical application of monobenzone in animals, increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans.

화학적 성질

4-Benzyloxyphenol is a cream to beige-light brownish crystals classified as a hydroquinone monobenzyl ether. It is soluble in alcohol, benzene and ether, and almost insoluble in water. 4-Benzyloxyphenol is a depigmenting agent that has the effect of enhancing the rate of elimination of melanin secreted by skin cells, and studies have shown that the molecular mechanism of its action may be related to tyrosinase.

용도

4-Benzyloxyphenol is used in the synthesis of bis(4-benzyloxyphenoxy)phenyl phosphine oxide. It plays an essential role in the preparation of hetaryl-azophenol dyes via heterocyclic amines in nitrosyl sulphuric acid. It is also used for polyester fiber dyeing and in rubber industry. It acts as a depigmenting agent.

Indications

Monobenzone (Benoquin) potently inhibits melanin production and destroys melanocytes. Like hydroquinone, monobenzone was originally introduced for the topical treatment of disorders of excess melanin pigmentation, including melasma. It is now used only to permanently depigment the remaining normally pigmented skin in patients with extensive vitiligo. Irritant and allergic contact dermatitis are common side effects.

정의

ChEBI: Monobenzone is the monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation. It has a role as a melanin synthesis inhibitor, a dermatologic drug and an allergen. It derives from a hydroquinone.

제조 방법

4-Benzyloxyphenol Synthesis: Add 2.63g (0.028mol) of hydroquinone to a 100mL conical flask, weigh 1.12g (0.028mol) of sodium hydroxide, add 8mL of water, wait for the sodium hydroxide to dissolve and add dropwise to the conical flask with hydroquinone, shake well, then add 15mL of DMF and 2.52g (0.02mol) of benzyl chloride, under microwave radiation power of 320W The reaction was cooled to room temperature at the end of the reaction. The reaction was first adjusted to alkalinity with 10% sodium hydroxide, filtered, and the filtrate was washed with 10% sodium hydroxide until the filtrate was colorless (the filtrate was hydroquinone bis(benzyl ether), which could be recycled). The filtrate was acidified with hydrochloric acid to make Monobenzone completely precipitated, and then washed by filtration and ice water, recrystallized with alcohol and water, and decolorized by activated carbon to obtain 2.55g of white solid, the yield was 63.79%.

부작용

Side effects:
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Intense itching, blistering, burning, or swelling of the skin.
Mild skin rash, tenderness, or redness.

Purification Methods

Crystallise it from EtOH or H2O, and dry (P2O5) under vacuum. [Walter et al. J Am Chem Soc 108 5210 1986, Beilstein 6 IV 5778.]

하이드로퀴논모노벤질에터 준비 용품 및 원자재

원자재

준비 용품

하이드로퀴논모노벤질에터 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Hubei Aumei New Material Co., Ltd.	+86-027-87366298 +8615927270571	tianyi@skbiology.cn	China	294	58
XI AN SGONEK BIOLOGICAL TECHNOLOGY CO., LTD	15202951039	jason@sgonekbio.com	China	268	58
Guangzhou Tengyue Chemical Co., Ltd.	+86-86-18148706580 +8618826483838	evan@tyvovo.com	China	154	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	326	58
Nanjing Deda New Material Technology Co., Ltd	+8613223293093	bella@njdeda.com	China	82	58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.	+86-029-86333380 18829239519	sales06@tgybio.com	China	942	58
Hebei Duling International Trade Co. LTD	+8618712993135	sales01@hbduling.cn	China	15734	58
Henan Tengmao Chemical Technology Co. LTD	+8615238638457	salesvip2@hntmhg.com	China	415	58

하이드로퀴논모노벤질에터 관련 검색: