ChemicalBook >제품 카탈로그 >API>항생제>농업 항생제>블레스티시딘-에스

블레스티시딘-에스

블레스티시딘-에스 구조식 이미지

카스 번호:: 2079-00-7

한글명:: 블레스티시딘-에스

동의어(한글):: 블라스티시딘-에스;블레스티시딘-에스;블라스티시딘-S;(2R,3R,6S)-3-[[(3S)-3-아미노-5-(카밤이미도일-메틸-아미노)펜탄오일]아미노]-6-(4-아미노-2-옥소-피리미딘-1-일)-3,6-다이하이드로-2H-피란-2-카복실산;(S)-4-[[3-아미노-5-[(아미노이미노메틸)메틸아미노]-1-옥소펜틸]아미노]-1-(4-아미노-2-옥소-1(2H)-피리미디닐)-1,2,3,4-테트라데옥시베타-D-에리트로-헥스-2-엔오피란유론산;1-(1'-시토신일)-4-(L-3'-아미노-5'-(1''-N-메틸구아니디노)발레릴아미노)-1,2,3,4-테트라데옥시-베타-D-에리트로-헥스-2-엔유론산;4-[[3-아미노-5-[(아미노이미노메틸)메틸아미노]-1-옥소펜틸]아미노-1-[4-아미노-2-옥소-1-(2H)-피리미딘일]-1,2,3,4-테트라데옥시-베타-D-에리트로-헥스-2-엔오피란유로산;4-[3-아미노-5-(1-메틸구아니디노)발레르아미도]-1-(4-아미노-2-옥소-1(2H)-피리미디닐)-1,2,3,4-테트라데옥시-D-에리트로-헥스-2-엔오피란유로산

상품명:: BLASTICIDIN S

동의어(영문):: blasticidin;bab;Blas;babs;Blaes;bcs-3;toabla-s;cytovirin;bcs-3、bla-s;blastizidin

CBNumber:: CB2269508

분자식:: C17H26N8O5

포뮬러 무게:: 422.45

MOL 파일:: 2079-00-7.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 50

블레스티시딘-에스 속성

녹는점: 235°C

끓는 점: 539.06°C (rough estimate)

알파: D11 +108.4° (water)

밀도: 1.1690 (rough estimate)

증기압: Low

굴절률: 1.6910 (estimate)

용해도: DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble; Water: soluble

물리적 상태: 고체

산도 계수 (pKa): 2.4 (carboxyl), 4.6,8.0 and>12.5 (three bases)

수용성: >30g l^-1(20°C)

안정성: 강한 산화제와 호환되지 않습니다.

EPA: Blasticidin S (2079-00-7)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	T+
위험 카페고리 넘버	28
안전지침서	24/25-36/37-45
유엔번호(UN No.)	3172
위험 등급	6.1(a)
포장분류	II
HS 번호	29349990
유해 물질 데이터	2079-00-7(Hazardous Substances Data)
독성	LD50 i.v. in mice: 2.82 mg/kg (Takeuchi)
기존화학 물질	KE-01170
유해화학물질 필터링	97-1-117
함량 및 규제정보	물질구분: 유독물질; 혼합물(제품)함량정보: 블라스티시딘-에스과 그 염류 및 그 중 하나를 1% 이상 함유한 혼합물

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H300	삼키면 치명적임	급성 독성 물질 - 경구	구분 1,2	위험		P264, P270, P301+P310, P321, P330,P405, P501

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P310	삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P321	(…) 처치를 하시오.
P330	입을 씻어내시오.
P405	밀봉하여 저장하시오.
P501	...에 내용물 / 용기를 폐기 하시오.

NFPA 704

	0
4		0

블레스티시딘-에스 C화학적 특성, 용도, 생산

개요

Nucleoside antibiotic produced by Streptomyces griseochromogenes (1). Biosynthesized from cytosine, glucose, arginine, and methionine (2).

용도

Blasticidin S is a nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations. Blasticidin S provided by BioAustralis is presented as the free base to avoid problems associated with the use of the hydrochloride.

정의

ChEBI: A blasticidin that is an antibiotic obtained from Streptomyces griseochromogene.

생산 방법

Blasticidin S is produced by Streptomyces griseochromogenes, and has a wide range of antimicrobial activity (4). This antibiotic was utilized in the Far East beginning in 1961 against the rice blast pathogen Pyricularia oryzae, with effective control achieved at rates of 10–40 ppm (4).

일반 설명

Blasticidin S was found in the culture broth of Streptomyces griseochromogenes by Yonehara et al. of the University of Tokyo in 1958. It has a nucleoside-analogue structure and shows strong activity against phytopathogenic fungi, especially Pericularia oryzae, the pathogen causing rice blast. Blasticidin S has been used to protect rice plants.

Pharmacology

Inhibits protein synthesis both in eukaryotes and in prokaryotes (5,6). Interacts with ribosomal RNA in large subunit, interfering with the transpeptidation step. Inhibits cell-free protein synthesis in P. oryzae and Escherichia coli.

신진 대사 경로

Several blasticidin S-resistant microorganisms are found to produce blasticidin S deaminase which catalyzes the hydrolytic deamination of the cytosine moiety in blasticidin S to give a non-toxic deaminohydroxy derivative.

신진 대사

3H-blasticidin S administered to mice was excreted in the urine and feces within 24 h. Cytomycin and cytosin were identified as the main metabolites in and on rice plants, respectively (7). In soil, DT₅₀ < 5 d. Metabolized to nontoxic deaminohydroxy blasticidin S by Aspergillus sp. and resistant Bacillus cereus. Novel deaminase and coding genes, BSD and bsr, were isolated as selectable marker genes for genetic engineering (8).

블레스티시딘-에스 준비 용품 및 원자재

원자재

VEGETABLEPROTEIN 디페닐메탄 streptomyces avermifilis BBK8 AMIKACIN SULFATE 크림

준비 용품

블레스티시딘-에스 공급 업체

글로벌( 50)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9126	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12338	58
Shandong Xiya Chemical Co., Ltd.	4009903999 13395398332	sales@xiyashiji.com	China	20810	60
Raw material medicin reagent co.,Ltd		sales@njromanme.com	China	4534	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58

블레스티시딘-에스 관련 검색:

클로로타로닐 디티아논 도데실벤젠 설파믹산 도데실벤젠 블레스티시딘-에스 DODECYLBENZENE H-BETA-ALA-BETA-ALA-OH Demethylblasticidin S BLASTICIDIN S HCL,BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES,BLASTICIDIN S HYDROCHLORIDE Blasticidin H blasticidin A blasticidin S deaminase BLASTICIDIN S HCL UN2811- blasticidin S-acetyltransferase Blasticidin S, HCl, Streptomyces griseochromogenes Blasticidin S sodium salt BLASTICIDIN S HCL,BLASTICIDIN S HYDROCHLORIDE,BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES,Blasticidin S benzylaminobenzenesulfonate