포름아미딘 아세트산
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포름아미딘 아세트산 속성
- 녹는점
- 158-161 °C (dec.)(lit.)
- 밀도
- 1.124
- 저장 조건
- Store below +30°C.
- 용해도
- 832g/L
- 물리적 상태
- 액체
- 색상
- 무색투명~연황색
- 수소이온지수(pH)
- 8 (400g/l, H2O, 20℃)
- 수용성
- 832g/L(21℃)
- 감도
- Hygroscopic
- BRN
- 3563488
- InChI
- InChI=1S/C2H4O2.CH4N2/c1-2(3)4;2-1-3/h1H3,(H,3,4);1H,(H3,2,3)
- InChIKey
- XPOLVIIHTDKJRY-UHFFFAOYSA-N
- SMILES
- C(C)(=O)O.C(=N)N
- CAS 데이터베이스
- 3473-63-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 43-36/37/38 | ||
| 안전지침서 | 36/37-37/39-26-36/37/39-27 | ||
| WGK 독일 | 2 | ||
| F 고인화성물질 | 3-9-21 | ||
| 자연 발화 온도 | 565 °C | ||
| TSCA | Yes | ||
| HS 번호 | 29252000 | ||
| 독성 | LD50 orally in Rabbit: 2510 mg/kg LD50 dermal Rat > 2000 mg/kg | ||
| 기존화학 물질 | KE-23192 |
포름아미딘 아세트산 C화학적 특성, 용도, 생산
개요
Formamidine acetate is an anti-tuberculosis drug that belongs to the class of aminoglycosides. It has been shown to have a potent cytotoxic effect on malignant brain cells in vitro. It inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. It also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.화학적 성질
white to light yellow crystalline powder용도
Formamidine acetate is used as an intermediate in the synthesis of active pharmaceutical ingredients. It is also used as a condensing agent for the preparation of pyrimidine and imidazole heterocycles.Purification Methods
Unlike the hydrochloride, the acetate salt is not hygroscopic. It is recrystallised from a small volume of acetic acid, by addition of EtOH and the crystals are washed with EtOH then Et2O and dried in a vacuum. [Taylor et al. Org Synth 46 39 1966, Beilstein 2 IV 82.]포름아미딘 아세트산 준비 용품 및 원자재
원자재
준비 용품
5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
5-METHOXY-QUINAZOLIN-4-YLAMINE
4-HYDROXY-5-NITROPYRIMIDINE
4,6-DIHYDROXY-5-METHYLPYRIMIDINE
4-히드록시-6-(트리플루오로메틸)피리미딘
4-chloro-5-fluoropyrimidine
4-Hydroxy-5-fluorpyrimidine
4-AMINOPYRIMIDINE-5-CARBONITRILE
6-CHLOROQUINAZOLIN-4-AMINE
4,6-Dimethylpyrimidine-5-carboxylic acid
4-Amino-6-methylpyrimidine-5-carbonitrile ,97%
5-[1-(2,3-디메틸페닐)에틸]-1H-이미다졸
6-Nitro-quinazolin-4-ylamine
4-이미다졸메탄올염화수소산염
4-AMINOPYRIMIDINE-5-CARBOXAMIDE
6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one
4-AMino-6-broMopyrrolo[1,2-f][1,2,4]triazine
4-Cyclopropyl-1(3)H-iMidazole
QUINAZOLIN-4-YLAMINE
ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE
포름아미딘 아세트산 공급 업체
글로벌( 554)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 |
info@edengenechem.com | China | 2169 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2141 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2966 | 58 |
| Baynoe Chem (Suzhou) Co., Ltd. | +86-512 65869404 +86-18934593683 |
sales06@baynoe.com | China | 292 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12470 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 6011 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 |
sales@myuchem.com | China | 6708 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 952 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21689 | 55 |