Vinorelbine
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Vinorelbine 속성
- 알파
- D20 +52.4° (c = 0.3 in CHCl3)
- 밀도
- 1.36±0.1 g/cm3(Predicted)
- 저장 조건
- Store at 4°C, protect from light
- 용해도
- >25.9mg/mL in DMSO
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 11.36±0.60(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| HS 번호 | 2939799090 | ||
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| 유해 물질 데이터 | 71486-22-1(Hazardous Substances Data) | ||
| 독성 | LD50 in mice (mg/m2): 72 i.v.; 78 orally (Mathé, Reizenstein) |
| 그림문자(GHS): |
 
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| 신호 어: | Danger | |||||||||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Vinorelbine C화학적 특성, 용도, 생산
개요
Vinorelbine is a semisynthetic vinca alkaloid differing from vinblastine in the catharantine moiety of the molecule. It is claimed to have a broad spectrum of action both in vifro and in vivo; clinically it has been found effective in the treatment of non-small cell lung cancer, advanced breast cancer, ovarian cancer and Hodgkins disease.용도
Vinorelbine base is an antineoplastic agent with anti-mitotic properties.정의
ChEBI: A vinca alkaloid with a norvinblastine skeleton.Pharmacokinetics
This semisynthetic alkaloid is unique in having oral bioavailability, but it currently is available only for IV injection. The initial phase elimination half-life is on par with that observed for vincristine and vinblastine, and the terminal phase half-life is between 28 and 44 hours.Clinical Use
Vinorelbine is particularly useful in the treatment of advanced non–small cell lung cancer and can be administered alone or in combination with cisplatin. It is thought to interfere with mitosis in dividing cells through a relatively specific action on mitotic microtubules.부작용
Although dose-limiting granulocytopenia is the major adverse effect, potentially fatal interstitial pulmonary changes have been noted, and patients with symptoms of respiratory distress should be promptly evaluated. As with all vinca alkaloids, elimination is primarily hepatobiliary, and dosage reduction should be considered in patients with liver dysfunction.Vinorelbine 준비 용품 및 원자재
원자재
3',4'-Anhydrovinblastine
Vinorelbine tartrate
부틸리튬
마그네슘
Vindoline
아세트산(빙초산)
브롬화알릴
수소화 리튬알미늄
에틸렌 디브롬
트리에틸아민
클로로포름산-1-클로로에틸에스테르
트리플루오로아세트 산
포르말린
나프탈리드나트륨
1-(페닐설포닐)인돌
준비 용품
Vinorelbine 공급 업체
글로벌( 215)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1142 | 58 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 |
sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Vinorelbine 관련 검색:
빈블라스틴 황산염, 모노수화물 미토미신 C 메토트렉세이트 에토포시드 빈크리스틴 황산염
Silibinin
VINORELBINE IMPURITY B
Vinorelbine tartrate
Vinorelbine (BICINS )
Vinorelbine Tartrate Injection
Vinorelbine-d3 Ditartrate
Vinorelbine Base
VINORELBINE RELATED COMPOUND A (25 MG) (4-O-DEACETYLVINORELBINE TARTRATE)
Vinorelbine Tartrare
Vinorelbine Tartarate
VINORELBINE [3H(G)]
VINORELBINE BI / DITARTARATE