AC-YVAD-CHO
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AC-YVAD-CHO 속성
- 끓는 점
- 937.7±65.0 °C(Predicted)
- 밀도
- 1.276±0.06 g/cm3(Predicted)
- 저장 조건
- −20°C
- 용해도
- DMF:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);10.15(Max Conc. mM)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 4.20±0.10(Predicted)
- 감도
- Moisture Sensitive
안전
| WGK 독일 | 3 |
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AC-YVAD-CHO C화학적 특성, 용도, 생산
개요
Ac-YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE; Ki = 0.76 nM) and an acetylated form of the caspase-1 inhibitor YVAD-CHO . It is selective for caspase-1 over caspase-4, -5, -8, -9, and -10 (Kis = 163-970 nM), as well as over caspase-2, -3, -6, and -7 (Kis = >10,000 nM for all). It inhibits activation of caspase-1 and IL-1β in a cell-free assay using LPS-treated THP-1 cell homogenates when used at a concentration of 5 μM. Ac-YVAD-CHO (12.5 μmol/kg) reduces pancreatic levels of IL-18 and serum levels of IL-1β, as well as reduces pyroptosis of pancreatic cells, in a mouse model of cerulein-induced acute pancreatitis but does not decrease pancreatic expression of NOD-like receptor protein 3 (NLRP3). It increases susceptibility to lethal E. coli infection but prevents LPS-induced death in C3H/HeN mice when administered at doses of 5 and 10 mg/kg, respectively.용도
A potent, specific, and reversible inhibitor of caspases-1, -4 and -5AC-YVAD-CHO 준비 용품 및 원자재
원자재
준비 용품
AC-YVAD-CHO 공급 업체
글로벌( 92)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10247 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; |
laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 27690 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 |
sales@nextpeptide.com | China | 19915 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49739 | 58 |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 |
support@tgpeptide.com | China | 3279 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 |
anna@api-made.com | China | 2944 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
AC-YVAD-CHO 관련 검색:
AC-LYS(AC)-D-ALA-D-ALA-OH
AC-WEHD-AMC
AC-ESMD-CHO
AC-WEHD-CHO
ICE INHIBITOR IV
N-acetyl-N-methyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-L-Alaninamide
AC-TYR-VAL-LYS(BIOTINYL)-ASP-2,6-DIMETHYLBENZOYLOXYMETHYLKETONE
ASN-GLU-ALA-TYR-VAL-HIS-ASP-ALA-PRO-VAL-ARG-SER-LEU-ASN
AC-YVAD-AFC
DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS
AC-YVAD-CMK
AC-TYR-(NME)VAL-ALA-(NME)ASP-CHO
MCA-TYR-VAL-ALA-ASP-ALA-PRO-LYS(DNP)-OH
AC-YVAD-PNA
N-ACETYL-TYR-VAL-LYS-ASP-AL
AC-YVAD-AMC
ICE INHIBITOR II, BIOTINYLATED,IL-1BETA CONVERTING ENZYME (ICE) INHIBITOR II, BIOTINYLATED
BIOTIN-TYR-VAL-ALA-ASP-CHO