안트랄린
|
|
안트랄린 속성
- 녹는점
- 178-181 °C (lit.)
- 끓는 점
- 464.1±45.0 °C(Predicted)
- 밀도
- 1.419±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- 물에 거의 녹지 않고, 염화메틸렌에 녹고, 아세톤에 조금 녹고, 에탄올에 약간 녹습니다(96%). 알칼리 수산화물의 묽은 용액에 용해됩니다.
- 산도 계수 (pKa)
- 7.16±0.20(Predicted)
- 색상
- 노란색에서 주황색, 진한 노란색까지
- 수용성
- 물에 불용성. 아세트산, 클로로포름(20 mg/mL), 아세톤, 벤젠, 알칼리 수산화물 용액, 고정 오일에 용해됩니다. 95% 에탄올, 알코올, 에테르 및 빙초산에 약간 용해됩니다.
- Merck
- 14,684
- BRN
- 2054360
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
- InChIKey
- NUZWLKWWNNJHPT-UHFFFAOYSA-N
- CAS 데이터베이스
- 1143-38-0(CAS DataBase Reference)
- IARC
- 3 (Vol. 13; Sup 7) 1987
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38-45 | ||
| 안전지침서 | 26-53-45 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | CB8927000 | ||
| HS 번호 | 29144000 |
안트랄린 C화학적 특성, 용도, 생산
개요
Anthralin is an anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation. It increases apoptosis and inhibits proliferation of normal human keratinocytes (NHKs) when used at a concentration of 2.5 μM. It also decreases the mitochondrial membrane potential, increases cytochrome c release, and induces perinuclear mitochondrial clustering in NHKs when used at a concentration of 5 μM. Anthralin (0.25 μM) decreases the expression of β-defensin-2 and S100 calcium-binding protein A9 (S100A9) and increases the expression of IL-6 and IL-8 in IL-17A- and IL-22-stimulated NHKs. It also inhibits leukotriene B4 (LTB4; ) production, stimulated by the calcium ionophore A23187 , from human neutrophils (IC50 = 7 μM). Topical anthralin (0.1%) induces hair regrowth in a Dundee experimental bald rat (DEBR) model of alopecia areata.화학적 성질
Yellow Crystalline Solid용도
AntipsoriaticIndications
Anthralin (Anthra-Derm) is a potent reducing agent whose mechanism of action is unknown. It is approved for the treatment of psoriasis and also may be helpful in alopecia areata. The major toxicities are discoloration of skin, hair, and nails and irritant dermatitis.정의
ChEBI: An anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9.일반 설명
Lemon yellow leaflets or plates or an orange powder. Melting point 176-181°C. No odor or taste. Insoluble in water. Moderately toxic by ingestion, inhalation and skin absorption. Used as a treatment for psoriasis.공기와 물의 반응
Unstable in air when in alkaline solution. Insoluble in water.반응 프로필
ANTHRALIN reacts as a weak acid. Soluble in aqueous bases. May react with strong oxidizing agents. May be sensitive to light and moisture .위험도
Very irritating. Do not use on scalp or near eyes.화재위험
Flash point data are not available for ANTHRALIN; however, ANTHRALIN is probably combustible.부작용
Anthralin's side effects include pruritus, erythema, scaling, folliculitis, and lymphadenopathy. Staining of skin and clothes can also be an issue.안트랄린 준비 용품 및 원자재
원자재
준비 용품
안트랄린 공급 업체
글로벌( 315)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 6011 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 |
salesvip2@hntmhg.com | China | 415 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15956 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |