ROTTLERIN
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ROTTLERIN 속성
- 녹는점
- 200 °C
- 끓는 점
- 521.39°C (rough estimate)
- 밀도
- 1.2051 (rough estimate)
- 굴절률
- 1.4900 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMSO에 용해됩니다(최대 50mg/ml).
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 6.92±0.40(Predicted)
- 색상
- 주황색에서 갈색으로
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO의 솔루션은 최대 1개월 동안 -20°에서 보관할 수 있습니다.
- LogP
- 8.660 (est)
- CAS 데이터베이스
- 82-08-6(CAS DataBase Reference)
안전
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 20/21/22-22 | ||
| 안전지침서 | 36/37-24/25 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | AM6913800 | ||
| HS 번호 | 29329990 |
ROTTLERIN C화학적 특성, 용도, 생산
화학적 성질
orange to brown powder용도
Rottlerin is a human ether-a-go-go-related gene (hERG) potassium channel activator.정의
ChEBI: A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.일반 설명
Rottlerin is extracted from Mallotus philippinensis. It is a protein kinase Cδ (PKCδ) inhibitor. Rottlerin acts as an uncoupler of mitochondrial respiration from oxidative phosphorylation. It has antitumor, autophagy, anti-proliferative, anti-metastasis and anti-invasive properties.생물학적 활성
Originally reported to inhibit PKC isoforms, with selectivity for PKC δ (K i values are 30, 42, 40, 3-6, 100, and 100 μ M for α , β , γ , δ , ε , λ respectively). Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC 50 values are 1.9 and 5 μ M respectively). Also shown to act as a direct mitochondrial uncoupler.ROTTLERIN 준비 용품 및 원자재
원자재
준비 용품
ROTTLERIN 공급 업체
글로벌( 134)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9641 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 |
info@aktinchem.com | CHINA | 1025 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 |
sales006@ingredients-lonier.com | China | 2605 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 |
sale@mainchem.com | China | 32360 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 |
shchemsky@sina.com | China | 15421 | 60 |
ROTTLERIN 관련 검색:
4-히드록시-3,5-디메틸벤즈알데히드 비스(2-하이드록시페닐)메테인 2,4,6-트라이메틸페놀 4'-히드록시-3',5'-디메틸아세토페논
2,2'-METHYLENEBIS(4-METHYLPHENOL)
3-Ethylacetophenone
3-VINYLBENZALDEHYDE
1-(2-Hydroxy-5-methylphenyl)ethanone
2',4'-DIHYDROXY-3'-METHYLACETOPHENONE
2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE
ROTTLERIN
2,4-Dihydroxy-3-methylbenzaldehyde
ALLYL P-TOLYL ETHER
3,5-DIMETHYLACETOPHENONE
2-ALLYLOXYBENZALDEHYDE
5-ETHYL-2-HYDROXY-BENZALDEHYDE
1-(2-ETHOXY-5-METHYL-PHENYL)-ETHANONE
2,4-DIHYDROXY-1,3,5-TRIMETHYLBENZENE