Endothelin-1 (human, porcine)

Endothelin-1 (human, porcine) C화학적 특성, 용도, 생산

용도

Endothelin-1 (human, porcine) has been used for coating wells in polystyrene ELISA plates. Potent agonist for ETA and ETB endothelia receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.

주요 응용

Endothelin-1 (human, porcine) has been used:
to study its effects on the production of erythropoietin under normoxia and carbon monoxide-induced hypoxia in rat models.
as a protein kinase C (PKC) agonist to study its effects on the phosphorylation of myofilament proteins in rat myocytes.
to induce a hypertrophic-like state to study its effects on contraction pressure in normal and mutated human induced pluripotent stem cells (hiPSC)-derived cardiomyocytes.
in vitro hydrolysis products of macroendothelin-1, a precursor of endothelin-1, and their pharmacodynamic properties in rabbits.
as a receptor for endothelin-1 and its role in G protein-mediated signal transduction Research.

Biological Functions

Endothelins are a family of vasoactive peptides secreted by endothelial cells. The three major endothelin peptides are all composed of 21 amino acids. Endothelins are the most potent vasoconstrictors known. Contraction of vascular smooth muscle in response to endothelin is associated with an increase in intracellular calcium. Increases in endothelin levels have been reported in patients with vasospastic, hypoxic, and ischemic diseases.The two identified isoforms of endothelin receptors have differing affinity for the three endothelin peptides. Selective and nonselective endothelin receptor antagonists are in development for potential use in the treatment of hypertension and other disorders associated with increased vascular resistance.

Biochem/physiol Actions

Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.

Endothelin-1 (human, porcine) 준비 용품 및 원자재

원자재

준비 용품

Endothelin-1 (human, porcine) 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9634	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10247	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	999	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12740	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58

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