Luteinizing hormone releasing hormone human acetate salt has been used:
for synchronization of the ovulations
for pre-absorption of the anti-GnRH antibody in staining procedures
to study pituitary sensitivity to GnRH in presence of endocrine disrupting compound
주요 응용
Gonadorelin acetate is widely used in the diagnosis of central precocious puberty.
Biochem/physiol Actions
Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.
부작용
Gonadorelin acetate is usually considered a safe medication. However, severe anaphylactic shock may occur after intravenous administration, manifested by loss of consciousness and tonic convulsions of the arms and legs; prompt treatment with epinephrine, diphenhydramine and fluids restores vital signs within 30 minutes. Therefore, it is recommended that these drugs be administered in an environment that is capable of handling systemic reactions.
